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Tbio
CALB2
Calretinin

Protein Summary
Description
Calretinin is a calcium-binding protein which is abundant in auditory neurons. This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302628
  • ENSP00000307508
  • ENSG00000172137
  • ENST00000635371
  • ENSP00000488916
  • ENSG00000282830

Symbol
  • CAB29
  • CR
  • CAL2
  • CAB29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.95
PubMedID
0.79
transcription factor perturbation
0.74
biological term
0.7
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2162.17   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 578   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2162.17   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0