Tdark | Small proline-rich protein 2D |
Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Comments
Disease | Target Count | P-value |
---|---|---|
psoriasis | 6685 | 0.0 |
diabetes mellitus | 1663 | 0.00104821351867176 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Seborrheic dermatitis | 19 | 4.248 | 2.1 |
PMID | Text |
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18643845 | Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. |
PMID | Year | Title |
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18643845 | 2009 | Association of psoriasis to PGLYRP and SPRR genes at PSORS4 locus on 1q shows heterogeneity between Finnish, Swedish and Irish families. |
16710414 | 2006 | The DNA sequence and biological annotation of human chromosome 1. |
16639001 | 2006 | Expression and regulation of cornified envelope proteins in human corneal epithelium. |
15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
15232223 | 2004 | Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus. |
14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. |
12786819 | 2003 | Differential expression of cornified cell envelope precursors in normal skin, intraorally transplanted skin and normal oral mucosa. |
12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |
11329013 | 2001 | Creation of genome-wide protein expression libraries using random activation of gene expression. |
11279051 | 2001 | Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function. |
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