Property Summary

NCBI Gene PubMed Count 84
PubMed Score 454.78
PubTator Score 303.65

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
non-small cell lung cancer 2798 4.03076997789833E-28
lung adenocarcinoma 2714 1.08826145337322E-12
malignant mesothelioma 3163 1.87914718642623E-9
juvenile dermatomyositis 1189 2.48157360857703E-8
acute quadriplegic myopathy 1157 3.35502040530011E-8
lung cancer 4473 1.88763802549724E-7
pilocytic astrocytoma 3086 1.34084606397487E-6
astrocytoma 1493 1.97072620128289E-6
intraductal papillary-mucinous adenoma (IPMA) 2956 9.23917121856119E-6
oligodendroglioma 2849 3.59605846124178E-5
tuberculosis 1563 5.35574883655755E-5
intraductal papillary-mucinous neoplasm (IPMN) 3289 1.05669978027723E-4
ductal carcinoma in situ 1745 1.87380548410255E-4
intraductal papillary-mucinous carcinoma (IPMC) 2988 2.04490314523879E-4
psoriasis 6685 4.06144316336234E-4
invasive ductal carcinoma 2950 4.24493994795435E-4
glioblastoma 5572 6.40766300095482E-4
pediatric high grade glioma 2712 6.74124940741601E-4
adrenocortical carcinoma 1427 7.01231118351649E-4
X-linked recessive Emery-Dreifuss muscular dystrophy 18 9.47693651777357E-4
limb girdle muscular dystrophy 2B 74 0.00123796537729511
fibroadenoma 557 0.00367407320479548
hepatocellular carcinoma 550 0.00395814873376223
breast carcinoma 1614 0.00445278984283187
colon cancer 1475 0.0126131025457917
primitive neuroectodermal tumor 3031 0.0128945817235465
ovarian cancer 8492 0.0155491229198286
diabetes mellitus 1663 0.0166673903724774
esophageal adenocarcinoma 737 0.0177058177470854
gastric cancer 436 0.0185165393756819
osteosarcoma 7933 0.0273455180898656
pancreatic carcinoma 567 0.0464143757262927
pancreatic cancer 2300 0.0464143757262931
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0464661704687138
posterior fossa group A ependymoma 1511 0.04711215445419
Disease Target Count Z-score Confidence
Keshan disease 14 4.271 2.1
Cancer 2346 3.395 1.7
Vascular disease 281 3.064 1.5



Accession P22352 O43787 Q86W78 Q9NZ74 Q9UEL1 GPx-3
Symbols GPx-P


PANTHER Protein Class (2)



  Ortholog (3)

Species Source
Chimp OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA Inparanoid

Gene RIF (70)

26662676 GPX1*Pro198Leu AND GPX3 rs2070593 as genetic risk markers for Italian asthmatic patients
26612412 A three-way interaction among maternal and fetal variants in BHMT2, GSTP1 and GPX3 contribute to congenital heart defects
26261521 GPX3 hypermethylation is frequent in chronic myeloid leukemia and is negatively associated with its expression.
26112936 GPX1, GPX3, and GPX4 genes may play a role in clear cell renal cell carcinoma cancerogenesis.
26045745 Reduced GPX3 expression is associated with favorable/intermediate karyotypes but not with survival in de novo acute myeloid leukemia patients.
25929866 GPX3 is frequently methylated in human papillary thyroid cancer and the expression of GPX3 was regulated by promoter region methylation
25445749 Our results suggest that promoter methylation may be a mechanism for inactivation of GPX3, possibly leading to subsequent carcinogenesis and progression of HCC
25333265 GPx3 is a tumor suppressor gene in HCC.
25126700 The T allele of -861A/T in GPX3 gene is a risk allele for the ischemic stroke phenotype.
24926085 APOA1 and GPX3 mRNA levels on qRT-PCR effectively differentiate ovarian from breast carcinoma.

AA Sequence

ILSYMRRQAALGVKRK                                                          211 - 226

Text Mined References (85)

PMID Year Title
26662676 2016 GPX1*Pro198Leu AND GPX3 rs2070593 as genetic risk markers for Italian asthmatic patients.
26612412 2016 A Three-Way Interaction among Maternal and Fetal Variants Contributing to Congenital Heart Defects.
26261521 2015 GPX3 promoter is methylated in chronic myeloid leukemia.
26112936 2015 Aberrant expression of selenium-containing glutathione peroxidases in clear cell renal cell carcinomas.
26045745 2015 Down-regulation of GPX3 is associated with favorable/intermediate karyotypes in de novo acute myeloid leukemia.
25929866 2015 Silencing GPX3 Expression Promotes Tumor Metastasis in Human Thyroid Cancer.
25445749 2015 Methylation of promoter and expression silencing of GPX3 gene in hepatocellular carcinoma tissue.
25416956 2014 A proteome-scale map of the human interactome network.
25333265 2014 Clinical significance and therapeutic value of glutathione peroxidase 3 (GPx3) in hepatocellular carcinoma.
25126700 2014 Screening of the GPX3 gene identifies the "T" allele of the SNP -861A/T as a risk for ischemic stroke in young Asian Indians.