TGM2
Protein-glutamine gamma-glutamyltransferase 2
Protein Summary
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000361475
- ENSP00000355330
- ENSG00000198959
- TGC
- TG(C)
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
transcription factor perturbation | 1 | ||
gene perturbation | 0.98 | ||
PubMedID | 0.94 | ||
small molecule perturbation | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2541.32 (req: < 5)
Gene RIFs: 403 (req: <= 3)
Antibodies: 1101 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2541.32 (req: >= 5)
Gene RIFs: 403 (req: > 3)
Antibodies: 1101 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 196
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0