Tclin COMT Catechol O-methyltransferase

Protein Summary

Description

Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol. Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• P21964
• A8MPV9
• Q6IB07
• Q6ICE6
• Q9BWC7

Gene Name

• COMT

Ensembl ID

• ENST00000361682
• ENSP00000354511
• ENSG00000093010
• ENST00000403710
• ENSP00000385917
• ENST00000406520
• ENSP00000385150
• ENST00000407537
• ENSP00000384654
• ENST00000449653
• ENSP00000416778

Symbol

• HEL-S-98n

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.96
biological process	0.91
transcription factor perturbation	0.88
disease	0.83
transcription factor	0.83

Protein Classes

PANTHER Classes

Protein / Transferase / Methyltransferase / Catechol O-methyltransferase

DTO Classes

Protein / Enzyme / Transferase / Methyltransferase / Catechol O-methyltransferase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4724.14   (req: < 5)

Gene RIFs: 1554   (req: <= 3)

Antibodies: 566   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4724.14   (req: >= 5)

Gene RIFs: 1554   (req: > 3)

Antibodies: 566   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 101

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4