| Tchem | D(4) dopamine receptor |
This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| NCBI Gene PubMed Count | 603 |
| Grant Count | 278 |
| R01 Count | 128 |
| Funding | $39,501,903.81 |
| PubMed Score | 707.09 |
| PubTator Score | 1219.26 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.100 | 0.008 |
| psoriasis | -1.500 | 0.000 |
aripiprazole lauroxil
pKi 7.36
flibanserin
pKi 8.40
cabergoline
pKi 7.30
terguride
pKi 8.10
pramipexole
pKi 9.31
apomorphine
pKi 8.05
amoxapine
pKi 7.47
rotigotine
pKi 7.26
lysergide
pKi 7.25
loxapine
pKi 8.31
zotepine
pKi 7.41
clebopride
pKi 8.49
tandospirone
pKi 8.14
nemonapride
pKd 9.68
ketanserin
pKi 8.46
spiperone
pKi 9.70
haloperidol
pKd 9.42
lisuride
pKi 8.30
perospirone
pKi 10.05
sertindole
pKi 7.96
CHEMBL294394
pKi 7.00
CHEMBL20729
pKi 7.00
CHEMBL484203
pKi 7.00
CHEMBL163239
pKi 7.00
CHEMBL201093
pKi 7.00
CHEMBL3792907
pIC50 7.00
CHEMBL105661
pKi 7.00
CHEMBL184772
pKi 7.00
CHEMBL126361
pEC50 7.00
CHEMBL1928139
pKi 7.00
CHEMBL2443006
pKi 7.00
CHEMBL67222
pKi 7.00
CHEMBL3792725
pIC50 7.00
CHEMBL2414354
pKi 7.00
CHEMBL239733
pKi 7.00
CHEMBL197162
pKi 7.00
CHEMBL3335555
pIC50 7.00
CHEMBL70267
pKi 7.01
CHEMBL318949
pKi 7.01
CHEMBL216258
pKi 7.01
| AID | Type | Active / Inconclusive / Inactive | Description |
|---|---|---|---|
| 1788 | other |
0 / 0 / 0 | Discovery of novel allosteric modulators of the M1 muscarinic receptor: Agonist Ancillary Activity |
| 1921 | other |
2 / 0 / 0 | Discovery of a Highly Selective in vitro and in vivo M4 Positive Allosteric Modulator: Ancillary Activity |
| 624355 | other |
0 / 0 / 0 | Late stage results from the probe development efforts to identify dual inhibitors of signal transducer and activator of transcription 3 (STAT3) and nuclear factor NF-kappa-B (NF-kB): Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs |
| 624406 | other |
0 / 0 / 0 | Late stage results from the probe development effort to identify inhibitors of Hepatitis C Virus (HCV) core protein dimerization: Cell-based radioligand binding assay to determine the binding affinities for selected transporters, receptors, and GPCRs |
| PMID | Text |
|---|---|
| 26688118 | present findings suggest that DRD4L may be involved in the development of an intermediate phenotype specific to substance abuse. |
| 26680992 | findings thus reveal unreported structural determinants of the mutated DRD4 receptor and provide a robust framework for design of effective novel drugs. |
| 26665568 | The observed frequency of dopamine DRD1 and DRD4 polymorphisms is similar to the distribution of these variants in other Caucasian populations |
| 26449981 | DRD4 48 bp VNTR polymorphism was not associated with nicotine craving in adolescent novice smokers. |
| 26439067 | DRD4 and a two-way interaction of birth weight and 6-month maternal attention and sensitivity predicted disorganized attachment. |
| 26427473 | Data show that six antibodies raised against DRD4 peptides were tested for immunoblot and immunohistochemistry applications. |
| 26424426 | Study demonstrated a moderating role for regulatory problems and DRD4 genotype in predicting the Child Behavior Checklist-dysregulation profile from maternal responsiveness |
| 26307064 | A total of 267 HIV-infected adults were genotyped for polymorphisms, DRD4 48 bp-variable number tandem repeat (VNTR), DRD2 rs6277 and ANKK1 rs1800497. |
| 26246555 | In a large sample of 1771 Han Chinese university students in Singapore, subjects with two copies of the 4-repeat allele (4R/4R) of the dopamine D4 receptor gene exon III repeat region were significantly more conservative. |
| 26037358 | Gender, age, education and the rs3758653 polymorphism of the DRD4 gene play an important role in cognitive functions in healthy adults. |
| More... |
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTN 1 - 70 SFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVP 71 - 140 LRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLL 141 - 210 LYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAP 211 - 280 AAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLP 281 - 350 PDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALC 351 - 420 PACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC 421 - 467 //
| PMID | Year | Title |
|---|---|---|
| 26688118 | 2016 | Dopamine D4 receptor VNTR polymorphism associated with greater risk for substance abuse among adolescents with disruptive behavior disorders: Preliminary results. |
| 26680992 | 2016 | Structural signatures of DRD4 mutants revealed using molecular dynamics simulations: Implications for drug targeting. |
| 26665568 | 2015 | DRD1 and DRD4 dopamine receptors in the etiology of preeclampsia. |
| 26449981 | 2015 | Parental smoke exposure and the development of nicotine craving in adolescent novice smokers: the roles of DRD2, DRD4, and OPRM1 genotypes. |
| 26439067 | 2015 | The interplay of birth weight, dopamine receptor D4 gene (DRD4), and early maternal care in the prediction of disorganized attachment at 36 months of age. |
| 26427473 | 2016 | Characterization of Antibodies to Identify Cellular Expression of Dopamine Receptor 4. |
| 26424426 | 2015 | Interacting effects of maternal responsiveness, infant regulatory problems and dopamine D4 receptor gene in the development of dysregulation during childhood: A longitudinal analysis. |
| 26307064 | 2015 | DRD2 and DRD4 genes related to cognitive deficits in HIV-infected adults who abuse alcohol. |
| 26246555 | 2015 | Association between the dopamine D4 receptor gene exon III variable number of tandem repeats and political attitudes in female Han Chinese. |
| 26037358 | 2015 | [Association of gender, age, education and polymorphism of DRD4 gene with cognitive functions in adults]. |
| More... |
