Tchem DRD4 D(4) dopamine receptor

Protein Summary

Description

Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity). This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P21917
• B0M0J7
• Q7Z7Q5
• Q8NGM5

Gene Name

• DRD4

Ensembl ID

• ENST00000176183
• ENSP00000176183
• ENSG00000069696

Symbol

• D4DR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
ligand (chemical)	0.97
drug	0.94
molecular function	0.88
disease	0.87

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / D(4) Dopamine Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Dopamine Receptor / D(4) Dopamine Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1183.26   (req: < 5)

Gene RIFs: 502   (req: <= 3)

Antibodies: 424   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1183.26   (req: >= 5)

Gene RIFs: 502   (req: > 3)

Antibodies: 424   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1479

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 37