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Tclin
FGFR2
Fibroblast growth factor receptor 2

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346997
  • ENSP00000263451
  • ENSG00000066468
  • ENST00000356226
  • ENSP00000348559
  • ENST00000357555
  • ENSP00000350166
  • ENST00000358487
  • ENSP00000351276
  • ENST00000359354
  • ENSP00000352309
  • ENST00000360144
  • ENSP00000353262
  • ENST00000369056
  • ENSP00000358052
  • ENST00000369058
  • ENSP00000358054
  • ENST00000369060
  • ENSP00000358056
  • ENST00000369061
  • ENSP00000358057
  • ENST00000457416
  • ENSP00000410294

Symbol
  • BEK
  • KGFR
  • KSAM
  • BEK
  • JWS
  • BBDS
  • CEK3
  • CFD1
  • ECT1
  • KGFR
  • TK14
  • TK25
  • BFR-1
  • CD332
  • K-SAM
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
PubMedID
1
phenotype
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1911.49   (req: < 5)
Gene RIFs: 523   (req: <= 3)
Antibodies: 1176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1911.49   (req: >= 5)
Gene RIFs: 523   (req: > 3)
Antibodies: 1176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 118
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 710
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6