| Tchem | Midkine |
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Comments
Property Summary
| Ligand Count | 3 |
| NCBI Gene PubMed Count | 143 |
| PubMed Score | 610.64 |
| PubTator Score | 121.16 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Anxiety Disorders | 38 | 0.0 | 0.0 |
| Diabetic Nephropathies | 37 | 0.0 | 0.0 |
| Glioma | 74 | 0.0 | 0.0 |
| Memory Disorders | 40 | 0.0 | 0.0 |
| Mesothelioma, Malignant | 105 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Diabetic Nephropathy | 34 |
| Schizophrenia | 1160 |
| malignant mesothelioma | 3232 |
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 2.3e-15 |
| Breast cancer | 3578 | 2.4e-05 |
| Disease | log2 FC | p |
|---|---|---|
| Breast cancer | 2.000 | 2.4e-05 |
| lung adenocarcinoma | 3.200 | 2.3e-15 |
