| Tchem | Midkine |
Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity).
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
Comments
Property Summary
| NCBI Gene PubMed Count | 136 |
| Grant Count | 69 |
| R01 Count | 40 |
| Funding | $6,076,977.48 |
| PubMed Score | 580.46 |
| PubTator Score | 121.16 |
| Disease | Z-score | Confidence |
|---|---|---|
| Cancer 2,346 | 4.518 | 2.3 |
| Anxiety Disorders 37 | ||
| Breast cancer 3,094 | ||
| Diabetic Nephropathy 37 | ||
| Glioma 65 | ||
| Memory Disorders 36 | ||
| lung adenocarcinoma 2,713 |
| Disease | log2 FC | p |
|---|---|---|
| lung adenocarcinoma | 3.200 | 0.000 |
| Breast cancer | 2.000 | 0.000 |
| PMID | Text |
|---|---|
| 27089523 | The concentration of MDK in amniotic fluid declined with gestational age.MDK concentrations in amniotic fluid were far higher than in maternal plasma. |
| 26656665 | MDK plays an important role in non-small cell lung cancer progression and prognosis and may act as a convincing prognostic indicator for non-small cell lung cancer patients. |
| 26642712 | PLSCR1 positively regulates hepatic carcinoma cell proliferation and migration through interacting with midkine |
| 26566633 | MK was significantly elevated in vitamin D deficiency and associated with anti-Saccharomyces cerevisiae antibodies positivity which was significantly increased in vitamin D deficiency |
| 26297257 | our results suggest that midkine expression could be a clinically useful marker in predicting the presence of multiple lymph node metastases in BRAFV600E papillary thyroid carcinoma. |
| 26159850 | overexpression of midkine protein serves as an unfavorable prognostic biomarker in breast cancer patients |
| 25817231 | midkine is as good as or even better than thyroglobulin to screen patients with thyroid nodules for differentiated thyroid cancer before surgery, and to predict whether metastases exist |
| 25787827 | The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture. |
| 25655295 | Use hybrid-type modified chitosan derivative nanoparticles to deliver midkine-siRNA to HepG2 cells. |
| 25428991 | SP1 directly up-regulated the expression of midkine (MDK), and the SP1-MDK axis cooperated in glioma tumorigenesis. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 27089523 | 2016 | Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies. |
| 26656665 | 2015 | MDK Protein Overexpression Correlates with the Malignant Status and Prognosis of Non-small Cell Lung Cancer. |
| 26642712 | 2015 | Phospholipid Scramblase 1 Interacts with Midkine and Regulates Hepatic Cancer Cell Proliferation and Migration. |
| 26566633 | 2016 | Midkine in vitamin D deficiency and its association with anti-Saccharomyces cerevisiae antibodies. |
| 26297257 | 2015 | Strong immunoexpression of midkine is associated with multiple lymph node metastases in BRAFV600E papillary thyroid carcinoma. |
| 26159850 | 2015 | The clinical and prognostic significance of midkine in breast cancer patients. |
| 25817231 | 2015 | Evaluation of serum midkine as a biomarker in differentiated thyroid cancer. |
| 25787827 | 2015 | The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture. |
| 25655295 | 2015 | Development of hybrid-type modified chitosan derivative nanoparticles for the intracellular delivery of midkine-siRNA in hepatocellular carcinoma cells. |
| 25428991 | 2015 | Transcriptional factor specificity protein 1 (SP1) promotes the proliferation of glioma cells by up-regulating midkine (MDK). |
| More... |
