Tclin C5AR1 C5a anaphylatoxin chemotactic receptor 1

Protein Summary

Description

Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a (PubMed:1847994, PubMed:8182049, PubMed:7622471, PubMed:9553099, PubMed:10636859, PubMed:15153520, PubMed:29300009). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (PubMed:8182049, PubMed:7622471, PubMed:9553099). Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:10636859, PubMed:15153520).

Uniprot Accession IDs

• P21730

Gene Name

• C5AR1

Ensembl ID

• ENST00000355085
• ENSP00000347197
• ENSG00000197405

Symbol

• C5AR
• C5R1
• C5A
• C5AR
• C5R1
• CD88

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
gene perturbation	0.83
protein domain	0.73
tissue sample	0.69
kinase	0.67

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / C5a Anaphylatoxin Chemotactic Receptor 1

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Anaphylatoxin Receptor / C5a Anaphylatoxin Chemotactic Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 821.09   (req: < 5)

Gene RIFs: 143   (req: <= 3)

Antibodies: 905   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 821.09   (req: >= 5)

Gene RIFs: 143   (req: > 3)

Antibodies: 905   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 181

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1