Tbio MAL Myelin and lymphocyte protein

Protein Summary

Description

Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function. The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq, May 2012]

Uniprot Accession IDs

• P21145
• Q6FH77

Gene Name

• MAL

Ensembl ID

• ENST00000309988
• ENSP00000310880
• ENSG00000172005
• ENST00000349807
• ENSP00000322860
• ENST00000353004
• ENSP00000306568
• ENST00000354078
• ENSP00000304924

Symbol

• MVP17
• VIP17

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.93
gene perturbation	0.67
cellular component	0.66
PubMedID	0.64
small molecule perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Myelin And Lymphocyte Protein

DTO Classes

Protein / Transporter / Myelin And Lymphocyte Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.41   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.41   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0