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Tchem
CDK11B
Cyclin-dependent kinase 11B

Protein Summary
Description
Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340677
  • ENSP00000464016
  • ENSG00000248333
  • ENST00000341832
  • ENSP00000463048
  • ENST00000407249
  • ENSP00000464036

Symbol
  • CDC2L1
  • CDK11
  • PITSLREA
  • PK58
  • p58
  • PK58
  • CDK11
  • CLK-1
  • CDC2L1
  • PITSLREA
  • p58CLK-1
  • CDK11-p46
  • CDK11-p58
  • p58CDC2L1
  • CDK11-p110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
transcription factor binding site profile
0.88
histone modification site profile
0.84
transcription factor
0.8
hub protein
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.39   (req: < 5)
Gene RIFs: 37   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.39   (req: >= 5)
Gene RIFs: 37   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0