Tclin CHRM3 Muscarinic acetylcholine receptor M3

Protein Summary

Description

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]

Uniprot Accession IDs

• P20309
• Q0VAJ8
• Q4QRI3
• Q5VXY2
• Q9HB60

Gene Name

• CHRM3

Ensembl ID

• ENST00000255380
• ENSP00000255380
• ENSG00000133019
• ENST00000615928
• ENSP00000482377

Symbol

• HM3
• PBS
• EGBRS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
ligand (chemical)	1
molecular function	0.93
biological process	0.89
biological term	0.89

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Muscarinic Acetylcholine Receptor M3

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Acetylcholine Receptor (Muscarinic) / Muscarinic Acetylcholine Receptor M3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.92   (req: < 5)

Gene RIFs: 131   (req: <= 3)

Antibodies: 360   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.92   (req: >= 5)

Gene RIFs: 131   (req: > 3)

Antibodies: 360   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1210

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 61