| Tclin | B-cell receptor CD22 |
Comments
| Disease | Target Count |
|---|---|
| Pre B-cell acute lymphoblastic leukemia | 5 |
| Disease | Target Count | P-value |
|---|---|---|
| osteosarcoma | 7950 | 4.0e-08 |
| posterior fossa group A ependymoma | 468 | 5.0e-07 |
| Pick disease | 1894 | 1.6e-04 |
| primary Sjogren syndrome | 735 | 2.2e-04 |
| nasopharyngeal carcinoma | 1058 | 2.7e-04 |
| psoriasis | 6694 | 6.1e-04 |
| Chronic Lymphocytic Leukemia | 262 | 3.8e-03 |
| group 4 medulloblastoma | 1855 | 4.1e-03 |
| adult high grade glioma | 3801 | 9.6e-03 |
| progressive supranuclear palsy | 676 | 1.0e-02 |
| interstitial cystitis | 2312 | 1.1e-02 |
| cutaneous lupus erythematosus | 1057 | 2.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cancer | 2499 | 5.346 | 2.7 |
| Systemic lupus erythematosus | 194 | 4.293 | 2.1 |
| Lymphoproliferative syndrome | 58 | 3.81 | 1.9 |
| Macroglobulinemia | 18 | 3.6 | 1.8 |
| Hepatic veno-occlusive disease | 16 | 3.189 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.200 | 9.6e-03 |
| Chronic Lymphocytic Leukemia | -1.197 | 3.8e-03 |
| cutaneous lupus erythematosus | 1.900 | 2.6e-02 |
| group 4 medulloblastoma | -1.300 | 4.1e-03 |
| interstitial cystitis | 1.600 | 1.1e-02 |
| nasopharyngeal carcinoma | -1.400 | 2.7e-04 |
| osteosarcoma | -2.607 | 4.0e-08 |
| Pick disease | -1.500 | 1.6e-04 |
| posterior fossa group A ependymoma | -1.100 | 5.0e-07 |
| primary Sjogren syndrome | 1.200 | 2.2e-04 |
| progressive supranuclear palsy | -1.300 | 1.0e-02 |
| psoriasis | 1.100 | 6.1e-04 |
CHEMBL502788
pIC50 6.00
CHEMBL501599
pIC50 6.05
CHEMBL509633
pIC50 6.33
CHEMBL509768
pIC50 6.40
CHEMBL502862
pIC50 6.62
CHEMBL511111
pIC50 6.64
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSK 1 - 70 FDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP 71 - 140 FPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQW 141 - 210 SHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWL 211 - 280 KDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVE 281 - 350 FLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK 351 - 420 KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSW 421 - 490 CSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDS 491 - 560 ISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWF 561 - 630 DWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILI 631 - 700 LAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEM 701 - 770 NIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENV 771 - 840 DYVILKH 841 - 847 //
