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Tclin B-cell receptor CD22

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

 Comments

Property Summary

Ligand Count 7
NCBI Gene PubMed Count 69
PubMed Score 829.04
PubTator Score 540.55

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (4)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 1.1
Kidney cancer 2613 0.0 0.6
Liver cancer 604 0.0 0.5

Expression

  Differential Expression (12)

Disease log2 FC p
adult high grade glioma -1.200 9.6e-03
Chronic Lymphocytic Leukemia -1.197 3.8e-03
cutaneous lupus erythematosus 1.900 2.6e-02
group 4 medulloblastoma -1.300 4.1e-03
interstitial cystitis 1.600 1.1e-02
nasopharyngeal carcinoma -1.400 2.7e-04
osteosarcoma -2.607 4.0e-08
Pick disease -1.500 1.6e-04
posterior fossa group A ependymoma -1.100 5.0e-07
primary Sjogren syndrome 1.200 2.2e-04
progressive supranuclear palsy -1.300 1.0e-02
psoriasis 1.100 6.1e-04

Synonym

Accession P20273 F5GYU4 F5H7U3 O95699 O95701 O95702 O95703 Q01665 Q32M46 Q92872 Q92873 Q9UQA6 Q9UQA7 Q9UQA8 Q9UQA9 Q9UQB0 Q9Y2A6
Symbols SIGLEC2
SIGLEC-2

Gene

CD22

PDB

5VKJ   5VKM   5VL3  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (19)

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 GO Function (1)

 GO Component (3)

 GO Process (1)

 Compartment GO Term (26)

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 IMPC Phenotype (4)

 MGI Phenotype (4)

 HCA RNA Cell Line (52)

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 CSPA Cell Line (9)

Pathway (12)

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Protein-protein Interaction (2)

S100A7   CPA4  

Drug (1)

No structure for inotuzumab ozogamicin

inotuzumab ozogamicin
pKd 9.70

Ligand (6)

Structure of CHEMBL502788

CHEMBL502788
pIC50 6.00

Structure of CHEMBL501599

CHEMBL501599
pIC50 6.05

Structure of CHEMBL509633

CHEMBL509633
pIC50 6.33

Structure of CHEMBL509768

CHEMBL509768
pIC50 6.40

Structure of CHEMBL502862

CHEMBL502862
pIC50 6.62

Structure of CHEMBL511111

CHEMBL511111
pIC50 6.64

Gene RIF (41)

AA Sequence 

MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSK      1 - 70
FDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERP     71 - 140
FPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQW    141 - 210
SHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWL    211 - 280
KDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVE    281 - 350
FLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPK    351 - 420
KVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSW    421 - 490
CSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDS    491 - 560
ISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWF    561 - 630
DWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILI    631 - 700
LAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEM    701 - 770
NIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENV    771 - 840
DYVILKH                                                                   841 - 847
//

Text Mined References (71)

PMID Year Title