Tbio TCN1 Transcobalamin-1

Protein Summary

Description

Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P20061
• A8KAC5
• Q8WV77
• TC-1

Gene Name

• TCN1

Ensembl ID

• ENST00000257264
• ENSP00000257264
• ENSG00000134827

Symbol

• TC1
• HC
• TC1
• TCI
• TC-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.83
PubMedID	0.73
small molecule perturbation	0.68
virus perturbation	0.68
trait	0.61

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.19   (req: < 5)

Gene RIFs: 25   (req: <= 3)

Antibodies: 185   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 347.19   (req: >= 5)

Gene RIFs: 25   (req: > 3)

Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0