Property Summary

NCBI Gene PubMed Count 39
PubMed Score 74.67
PubTator Score 41.52

Knowledge Summary


No data available


  Disease Sources (3)

Disease Target Count P-value
psoriasis 6685 8.20510295192379E-45
non-small cell lung cancer 2798 2.56644853303201E-16
ulcerative colitis 2087 1.25057247700141E-11
posterior fossa group A ependymoma 1511 1.0256671635051E-8
malignant mesothelioma 3163 1.12237528406544E-7
lung cancer 4473 3.87048973868384E-7
tuberculosis 1563 6.73485679718195E-6
lung adenocarcinoma 2714 4.42308029662571E-5
head and neck cancer 270 1.53986538916846E-4
pancreatic cancer 2300 1.63327496467302E-4
cystic fibrosis 1670 6.91300736481838E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00461460551872019
nasopharyngeal carcinoma 1056 0.0103226518706024
active Crohn's disease 918 0.0152147062560324
ovarian cancer 8492 0.0165106132883175
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0183728155624381
esophageal adenocarcinoma 737 0.0254498837300123
spina bifida 1064 0.026905982052635
interstitial cystitis 2299 0.0289578040533906
gastric carcinoma 832 0.0306130240347339
Barrett's esophagus 185 0.0346543987280131
colon cancer 1475 0.0352930050980546
Disease Target Count Z-score Confidence
Influenza 142 3.549 1.8


  Differential Expression (22)

Disease log2 FC p
malignant mesothelioma -3.900 0.000
Barrett's esophagus 1.700 0.035
esophageal adenocarcinoma 2.000 0.025
posterior fossa group A ependymoma 3.500 0.000
cystic fibrosis 3.300 0.001
tuberculosis -5.100 0.000
non-small cell lung cancer -2.788 0.000
intraductal papillary-mucinous adenoma (... 1.800 0.005
intraductal papillary-mucinous neoplasm ... 1.900 0.018
colon cancer 2.000 0.035
lung cancer -5.500 0.000
active Crohn's disease 3.572 0.015
ulcerative colitis 5.100 0.000
pancreatic cancer 2.100 0.000
interstitial cystitis 1.500 0.029
nasopharyngeal carcinoma 1.300 0.010
lung adenocarcinoma -1.465 0.000
spina bifida -1.544 0.027
gastric carcinoma 2.700 0.031
ovarian cancer 1.200 0.017
head and neck cancer 1.900 0.000
psoriasis 2.100 0.000


Accession P19876 Q4W5H9
Symbols GRO3


  Ortholog (4)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG
Cow OMA Inparanoid
Opossum OMA Inparanoid

Gene RIF (20)

24605943 results support a functional role of CXCL3 in breast cancer metastasis and as a viable target for cancer therapy
23904157 our results demonstrate the diverse mechanisms by which CXCL2 and CXCL3 mediate normal and asthmatic airway smooth muscle cell migration
23589610 secreted growth-regulated oncogene chemokines, specifically GRO-gamma, in human Mesenchymal stromal cell-conditioned media have an effect on the differentiation and the function of human monocyte-derived dendritic cells.
23383108 A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of chemokine (C-X-C motif) ligand 3 (CXCL3) in peptide-treated PBMCs
23225384 This study demonistrated that CXCL1, CXCL2, CXCL3, CXCL8, and CXCL11, absent from normal muscle fibers, were induced in DMD myofibers.
23023221 Data show that mesenchymal stem cells (MSCs) directly regulate T cell proliferation by induction of CXCL3 chemokine and its receptor, CXCR2 on the surface in T cells.
20628624 Meta-analysis of gene-disease association. (HuGE Navigator)
20503287 Observational study of gene-disease association. (HuGE Navigator)
20237496 Observational study of gene-disease association. (HuGE Navigator)
20162422 A significantly increased expression of GRO-2, GRO-3, and IL-8 in colon carcinoma as compared to normal tissue, is reported.

AA Sequence

QTEVIATLKNGKKACLNPASPMVQKIIEKILNKGSTN                                      71 - 107

Text Mined References (40)

PMID Year Title
24605943 2014 CXCL3 is a potential target for breast cancer metastasis.
23904157 2013 Differential roles of CXCL2 and CXCL3 and their receptors in regulating normal and asthmatic airway smooth muscle cell migration.
23589610 2013 Mesenchymal stem cells tune the development of monocyte-derived dendritic cells toward a myeloid-derived suppressive phenotype through growth-regulated oncogene chemokines.
23225384 2012 Upregulation of chemokines and their receptors in Duchenne muscular dystrophy: potential for attenuation of myofiber necrosis.
23128233 2012 Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
23023221 2012 Mesenchymal stem cells regulate the proliferation of T cells via the growth-related oncogene/CXC chemokine receptor, CXCR2.
20628624 2010 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
20503287 2010 Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
20162422 2010 Differential expression of the chemokines GRO-2, GRO-3, and interleukin-8 in colon cancer and their impact on metastatic disease and survival.