Tchem PLCG1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Protein Summary

Description

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration. The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P19174
• B7ZLY7
• B9EGH4
• E1P5W4
• Q2V575

Gene Name

• PLCG1

Ensembl ID

• ENST00000244007
• ENSP00000244007
• ENSG00000124181
• ENST00000373271
• ENSP00000362368

Symbol

• PLC1
• PLC1
• NCKAP3
• PLC-II
• PLC148
• PLCgamma1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
protein domain	1
biological process	0.99
kinase	0.99
pathway	0.98

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-1

Protein / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-1

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-1

Protein / Calcium-binding Protein / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-1

DTO Classes

Protein / Enzyme / Hydrolase / Lipase / Phospholipase / 1-phosphatidylinositol 4,5-bisphosphate Phosphodiesterase Gamma-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 945.19   (req: < 5)

Gene RIFs: 154   (req: <= 3)

Antibodies: 1052   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 945.19   (req: >= 5)

Gene RIFs: 154   (req: > 3)

Antibodies: 1052   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0