Property Summary

NCBI Gene PubMed Count 270
PubMed Score 1682.04
PubTator Score 901.30

Knowledge Summary


No data available


  Disease Sources (2)

Disease Target Count P-value
non-small cell lung cancer 2798 1.04704105543529E-20
lung carcinoma 2844 2.06421123141959E-20
pancreatic cancer 2300 1.80589437212634E-9
lung adenocarcinoma 2714 2.01807268970141E-7
atypical teratoid / rhabdoid tumor 4369 1.27716845845841E-6
osteosarcoma 7933 2.33698941366918E-6
malignant mesothelioma 3163 9.93224507933814E-6
pediatric high grade glioma 2712 7.20839666775746E-5
ductal carcinoma in situ 1745 1.4026794740876E-4
psoriasis 6685 1.47869050741811E-4
cystic fibrosis 1670 1.5778297910989E-4
ovarian cancer 8492 2.25424152423072E-4
interstitial cystitis 2299 4.05424529206169E-4
medulloblastoma, large-cell 6234 7.95677520685477E-4
glioblastoma 5572 8.39755573409783E-4
ependymoma 2514 0.00110259066602412
primitive neuroectodermal tumor 3031 0.00268595016676649
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00289983222443744
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00325531015775797
invasive ductal carcinoma 2950 0.0046485640968675
breast carcinoma 1614 0.00571131429120949
inflammatory breast cancer 404 0.00592787558663073
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00982605464009662
nephrosclerosis 329 0.0155170790382688
primary pancreatic ductal adenocarcinoma 1271 0.0292797283263887
spina bifida 1064 0.0323716509320221
sonic hedgehog group medulloblastoma 1482 0.0324962944703606
fibroadenoma 557 0.0411541103553151



Accession P18827 D6W523 Q53QV0 Q546D3 Q96HB7 SYND1
Symbols SDC



4GVC   4GVD  

  Ortholog (11)

 GWAS Trait (1)

Gene RIF (241)

26909794 The results suggest that Sdc1 may modulate fibronectin fibrillogenesis and/or alter cell morphology during ECM production through alphavbeta3 integrin, thereby mediating ECM fiber alignment.
26852939 Syndecan-1 on epithelial tumor cells promotes MIF binding and MIF-mediated cell migration. This may represent a relevant mechanism through which MIF enhances tumor cell motility and metastasis.
26729247 The new markers were able to identify a clonal CD138-negative population as minimal residual disease in the bone marrow and peripheral blood of MM patients.
26514209 miR-145 suppresses syndecan-1 and, by this mechanism, up-regulates stem cell factors and induces cell senescence and differentiation.
26513873 stromal changes in the expression of SDC-1 may originate from the stroma and contribute to the pathogenesis and metastatic potential of epithelial ovarian carcinoma
26460958 Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts.
26350464 demonstrate that HER2 is captured via a site, comprised of amino acids 210-240, in the extracellular domain of human Sdc1, and EGFR is captured via an extracellular site comprised of amino acids 87-131 in human Sdc4
26289843 HPV16 particles binds to heparan sulfate and syndecan-1 molecules present in the extracellular matrix.
26210886 SULF1 levels are lower in pleural malignancies compared to benign conditions and inversely correlate with the amounts of syndecan-1, suggesting important roles for syndecan-1 and SULF1 in malignant mesothelioma.
26191180 miR-302a plays a key role in inhibition of ovarian cancer cell proliferation, and enhancing apoptosis by targeting SDC1.

AA Sequence

KDEGSYSLEEPKQANGGAYQKPTKQEEFYA                                            281 - 310

Text Mined References (277)

PMID Year Title
26909794 2016 Syndecan-1-Induced ECM Fiber Alignment Requires Integrin ?v?3 and Syndecan-1 Ectodomain and Heparan Sulfate Chains.
26852939 2016 Cell surface syndecan-1 contributes to binding and function of macrophage migration inhibitory factor (MIF) on epithelial tumor cells.
26729247 2016 A CD138-independent strategy to detect minimal residual disease and circulating tumour cells in multiple myeloma.
26514209 2015 microRNA-145 promotes differentiation in human urothelial carcinoma through down-regulation of syndecan-1.
26513873 2015 Syndecan-1 serves as a marker for the progression of epithelial ovarian carcinoma.
26460958 2015 Targeting Syndecan-1, a molecule implicated in the process of vasculogenic mimicry, enhances the therapeutic efficacy of the L19-IL2 immunocytokine in human melanoma xenografts.
26350464 2015 Syndecan-1 and Syndecan-4 Capture Epidermal Growth Factor Receptor Family Members and the ?3?1 Integrin Via Binding Sites in Their Ectodomains: NOVEL SYNSTATINS PREVENT KINASE CAPTURE AND INHIBIT ?6?4-INTEGRIN-DEPENDENT EPITHELIAL CELL MOTILITY.
26289843 2015 Interaction of human papillomavirus type 16 particles with heparan sulfate and syndecan-1 molecules in the keratinocyte extracellular matrix plays an active role in infection.
26210886 2015 Syndecan-1 alters heparan sulfate composition and signaling pathways in malignant mesothelioma.
26191180 2015 MiR-302a inhibits the tumorigenicity of ovarian cancer cells by suppression of SDC1.