Tclin SRD5A1 3-oxo-5-alpha-steroid 4-dehydrogenase 1

Protein Summary

Description

Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). Also see SRD5A2 (MIM 607306).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• P18405
• B2R7Q1
• Q9UHY4
• Q9UP36
• Q9UP37

Gene Name

• SRD5A1

Ensembl ID

• ENST00000274192
• ENSP00000274192
• ENSG00000145545

Symbol

• S5AR 1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.87
transcription factor perturbation	0.8
transcription factor binding site profile	0.77
kinase perturbation	0.76
virus perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / 3-oxo-5-alpha-steroid 4-dehydrogenase 1

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / 3-oxo-5-alpha-steroid 4-dehydrogenase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.68   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 158   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.68   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 158   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 325

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2