ADRA2B
Alpha-2B adrenergic receptor
Protein Summary
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
- ENST00000620793
- ENSP00000480573
- ENSG00000274286
- ADRA2L1
- ADRA2RL1
- FAME2
- ADRA2L1
- ADRARL1
- ADRA2RL1
- ALPHA2BAR
- alpha-2BAR
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
biological process | 0.95 | ||
ligand (chemical) | 0.94 | ||
cell type or tissue | 0.76 | ||
biological term | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 168.79 (req: < 5)
Gene RIFs: 92 (req: <= 3)
Antibodies: 0 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 168.79 (req: >= 5)
Gene RIFs: 92 (req: > 3)
Antibodies: 0 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 121
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 54