Tchem ALOX12 Arachidonate 12-lipoxygenase, 12S-type

Protein Summary

Description

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P18054
• O95569
• Q6ISF8
• Q9UQM4
• 12S-LOX

Gene Name

• ALOX12

Ensembl ID

• ENST00000251535
• ENSP00000251535
• ENSG00000108839

Symbol

• 12LO
• LOG12
• LOG12
• 12-LOX
• 12S-LOX

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
protein domain	0.92
biological term	0.77
disease	0.73
molecular function	0.73

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Arachidonate 12-lipoxygenase, 12s-type

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Arachidonate 12-lipoxygenase, 12s-type

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 409.48   (req: < 5)

Gene RIFs: 115   (req: <= 3)

Antibodies: 214   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 409.48   (req: >= 5)

Gene RIFs: 115   (req: > 3)

Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 45

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2