Tclin TPH1 Tryptophan 5-hydroxylase 1

Protein Summary

Description

This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.[provided by RefSeq, Apr 2009]

Uniprot Accession IDs

• P17752
• D3DQX6
• O95188
• O95189
• Q16736
• Q3KPG8

Gene Name

• TPH1

Ensembl ID

• ENST00000250018
• ENSP00000250018
• ENSG00000129167

Symbol

• TPH
• TPRH
• TRPH
• TPRH
• TRPH

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
disease	0.72
gene perturbation	0.67
molecular function	0.63
biological process	0.59

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1143.33   (req: < 5)

Gene RIFs: 137   (req: <= 3)

Antibodies: 545   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1143.33   (req: >= 5)

Gene RIFs: 137   (req: > 3)

Antibodies: 545   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 163

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1