Property Summary

NCBI Gene PubMed Count 40
Grant Count 183
R01 Count 94
Funding $29,995,020.44
PubMed Score 1499.14
PubTator Score 152.94

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (3)

Disease log2 FC p
lung adenocarcinoma -1.100 0.000
invasive ductal carcinoma -1.458 0.001
ovarian cancer -1.100 0.001

Synonym

Accession P17707 E1P5F7 Q5VXN4 Q5VXN6 Q9BWK4 AdoMetDC
Symbols AMD
SAMDC
ADOMETDC

Gene

PANTHER Protein Class (2)

PDB

1I72   1I79   1I7B   1I7C   1I7M   1JEN   1JL0   1MSV   3DZ2   3DZ3   3DZ4   3DZ5   3DZ6   3DZ7   3EP3   3EP4   3EP5   3EP6   3EP7   3EP8   3EP9   3EPA   3EPB   3H0V   3H0W  

Gene RIF (18)

PMID Text
26558825 AMD1 gene variants previously found to associate among Indian children did not associate with risk of obesity or obesity-related quantitative measures among Caucasian children and juvenile men from Denmark.
24652003 (AMD1)-mediated mRNA processing and cell adhesion activated & inhibited transition mechanisms
23260169 Gene expression studies have identified altered expression of AMD1 in suicide completers with a history of mood disorders.
22496743 Genetic variant of AMD1 is associated with obesity.
22008221 This study demomistrated that H3K4me3 modification plays an important role in up regulation of AMD1 in prefrontal cortex.
21134486 Overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts led to aggressive transformants.
20615890 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
20215859 Decreased AMD1 is associated with prostate cancer.
19661236 Observational study of gene-disease association. (HuGE Navigator)
19527050 determined crystal structures cocrystallized with 5'-deoxy-5'-dimethylthioadenosine and 5'-deoxy-5'-(N-dimethyl)amino-8-methyladenosine. The crystal structures revealed cation-pi interaction between the ligand and aromatic side chains of Phe7 and Phe223
More...

AA Sequence

MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSM      1 - 70
FVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAI     71 - 140
FPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIR    141 - 210
DLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKF    211 - 280
VTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS                    281 - 334
//

Text Mined References (42)

PMID Year Title
26558825 2015 Common variants in LEPR, IL6, AMD1, and NAMPT do not associate with risk of juvenile and childhood obesity in Danes: a case-control study.
24652003 2014 Adenosylmethionine decarboxylase 1 (AMD1)-mediated mRNA processing and cell adhesion activated & inhibited transition mechanisms by different comparisons between chimpanzee and human left hemisphere.
23260169 2013 Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide.
22496743 2012 Genetic variant of AMD1 is associated with obesity in urban Indian children.
22008221 2012 Effects of histone modifications on increased expression of polyamine biosynthetic genes in suicide.
21134486 2011 Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase.
20615890 2010 A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.
20215859 2010 Assessing prostate cancer growth with mRNA of spermine metabolic enzymes.
19661236 2009 Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes.
19527050 2009 Role of the sulfonium center in determining the ligand specificity of human s-adenosylmethionine decarboxylase.
More...