Tchem | Tyrosine-protein phosphatase non-receptor type 2 |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]
Comments
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2798 | 1.44451176533604E-10 |
ovarian cancer | 8492 | 1.47314291465383E-10 |
osteosarcoma | 7933 | 7.26868771947708E-7 |
Pick disease | 1893 | 1.81289887326571E-5 |
malignant mesothelioma | 3163 | 3.66606533665575E-5 |
glioblastoma | 5572 | 1.8075300771852E-4 |
group 3 medulloblastoma | 2254 | 0.00598144508087531 |
ependymoma | 2514 | 0.0137985100956015 |
Alzheimer's disease | 644 | 0.0258386661274959 |
progressive supranuclear palsy | 674 | 0.0268114422345482 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Crohn's disease | 304 | 4.235 | 2.1 |
Rheumatoid Arthritis | 1171 | 3.063 | 1.5 |
Alopecia areata | 37 | 0.0 | 2.0 |
Celiac disease | 112 | 0.0 | 2.0 |
Motor neuron disease | 39 | 0.0 | 1.0 |
Type 1 diabetes mellitus | 104 | 0.0 | 2.0 |
Disease | Target Count |
---|---|
Juvenile rheumatoid factor-negative polyarthritis | 9 |
Oligoarticular juvenile arthritis | 9 |
Disease | log2 FC | p |
---|---|---|
malignant mesothelioma | 1.600 | 0.000 |
ependymoma | 1.200 | 0.014 |
osteosarcoma | 2.635 | 0.000 |
glioblastoma | 1.400 | 0.000 |
non-small cell lung cancer | -1.070 | 0.000 |
group 3 medulloblastoma | 1.300 | 0.006 |
Alzheimer's disease | 1.100 | 0.026 |
Pick disease | 1.700 | 0.000 |
progressive supranuclear palsy | 1.100 | 0.027 |
ovarian cancer | -1.900 | 0.000 |
Species | Source |
---|---|
Chimp | OMA EggNOG |
Mouse | OMA EggNOG Inparanoid |
Rat | OMA Inparanoid |
Dog | OMA Inparanoid |
Horse | OMA EggNOG |
Cow | OMA EggNOG Inparanoid |
Pig | OMA EggNOG |
Opossum | OMA EggNOG Inparanoid |
Chicken | OMA EggNOG Inparanoid |
Anole lizard | OMA EggNOG Inparanoid |
Xenopus | OMA EggNOG Inparanoid |
Zebrafish | OMA EggNOG Inparanoid |
CHEMBL56711
pKi 6.00
CHEMBL379196
pKi 6.00
CHEMBL1938829
pIC50 6.00
CHEMBL1163239
pIC50 6.01
CHEMBL1242827
pIC50 6.01
CHEMBL1242363
pIC50 6.02
CHEMBL266753
pIC50 6.03
CHEMBL55799
pKi 6.05
CHEMBL1938816
pIC50 6.06
CHEMBL1938828
pIC50 6.06
CHEMBL504291
pIC50 6.07
CHEMBL448797
pIC50 6.07
CHEMBL292849
pKi 6.09
CHEMBL214378
pKi 6.09
CHEMBL445491
pIC50 6.10
CHEMBL1241469
pIC50 6.10
CHEMBL3098857
pIC50 6.10
CHEMBL3822604
pIC50 6.12
CHEMBL443663
pIC50 6.13
CHEMBL450403
pIC50 6.13
PMID | Text |
---|---|
26734582 | role of PTPN2 in type 1 diabetes and Crohn's disease (review) |
26344020 | rs2542151 SNP in The PTPN2 gene is associated with T1DM in Chinese Han children |
26208487 | Loss of protein tyrosine phosphatase, non-receptor type 2 is associated with activation of AKT and tamoxifen resistance in breast cancer. |
26139109 | PTPN2 is linked to the pathogenesis of rheumatoid arthritis via synovial fibroblasts. It is a regulator of lnterleukin-6 production in rheumatoid arthritis synovial fibroblasts. |
26090670 | Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin |
26026268 | demonstrate that SIPAR directly interacts with T cell protein tyrosine phosphatase TC45 and enhances its association with STAT3 |
25492475 | dysfunction of PTPN2 results in aberrant T-cell differentiation and intestinal dysbiosis similar to those observed in human CD. Our findings indicate a novel and crucial role for PTPN2 in chronic intestinal inflammation. |
25489960 | Single-nucleotide polymorphism in PTPN2 gene is associated with Crohn's disease. |
25460303 | PTPN2 and genes of the vitamin D pathway may have roles in risk of juvenile idiopathic arthritis |
25311528 | FGFR3 regulation by PTPN1 and PTPN2 depend on FGFR3 localization and A-loop sequence. |
More... |
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYIN 1 - 70 ASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETG 71 - 140 FSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHG 141 - 210 PAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIK 211 - 280 GDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALR 281 - 350 KRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL 351 - 415 //
PMID | Year | Title |
---|---|---|
26734582 | 2015 | Genetic Variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn's Disease. |
26344020 | 2015 | Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus. |
26208487 | 2015 | Loss of protein tyrosine phosphatase, non-receptor type 2 is associated with activation of AKT and tamoxifen resistance in breast cancer. |
26139109 | 2015 | Protein tyrosine phosphatase nonreceptor type 2: an important regulator of lnterleukin-6 production in rheumatoid arthritis synovial fibroblasts. |
26090670 | 2015 | Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin. |
26026268 | 2015 | Nuclear termination of STAT3 signaling through SIPAR (STAT3-Interacting Protein As a Repressor)-dependent recruitment of T cell tyrosine phosphatase TC-PTP. |
25492475 | 2015 | PTPN2 controls differentiation of CD4? T cells and limits intestinal inflammation and intestinal dysbiosis. |
25489960 | 2015 | Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans. |
25460303 | 2015 | Epistasis amongst PTPN2 and genes of the vitamin D pathway contributes to risk of juvenile idiopathic arthritis. |
25311528 | 2015 | Differential regulation of FGFR3 by PTPN1 and PTPN2. |
More... |