Property Summary

NCBI Gene PubMed Count 106
Grant Count 6
R01 Count 6
Funding $456,116
PubMed Score 45.42
PubTator Score 241.85

Knowledge Summary

Patent

No data available

Expression

Protein-protein Interaction (5)

Gene RIF (72)

PMID Text
26358320 Taken together, our results demonstrated the deregulation of GAS2 in both AML and ALL and the requirement of GAS2-Calpain2 axis for the growth of leukemic cells.
26248159 Calpain-2 modulates pulmonary vascular remodeling in pulmonary arterial hypertension.
25944670 The combination of Ca2+ and ionomycin was required to activate calpain 2, resulting in the further degradation of Dicer and the appearance of a degradation product similar to that detected in platelets from some diabetic individuals.
23940116 The data reveal that hGAAP is a novel regulator of focal adhesion dynamics, cell adhesion, and migration by controlling localized Ca(2+)-dependent activation of calpain 2.
23889979 In a transgenic mouse model, hypoxia-triggered m-calpain activation is involved in endoplasmic reticulum stress-mediated Alzheimer's disease pathogenesis.
23733271 Small interfering RNA (siRNA)-mediated silencing of m-calpain expression significantly suppressed the adhesive, migrative and invasive potentials of human hepatoma cells.
23538341 alpha-II spectrin was drastically accumulated in infected T cells derived from adult T-cell leukemia patients, whereas its digestive protease calpain-2 (CAN2) was significantly downregulated.
23466492 The carboxyl tail of alpha-actinin-4 regulates its susceptibility to m-calpain and thus functions in cell migration and spreading.
23389291 data demonstrate that GSK-3beta plays an important role in regulating tRXRalpha production by calpain II in cancer cells
23140395 The results suggest that calpain-2 and calpastatin expression is important in pancreatic cancers, influencing disease progression
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AA Sequence

MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKT      1 - 70
RGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFH     71 - 140
FQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGG    141 - 210
IAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQK    211 - 280
LIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTS    281 - 350
DTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQR    351 - 420
KMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFE    421 - 490
PNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRV    491 - 560
LAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKA    561 - 630
LEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL    631 - 700
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Publication (110)

PMID Year Title
26358320 2015 GAS2-Calpain2 axis contributes to the growth of leukemic cells.
26248159 2016 Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.
25944670 2015 Dicer cleavage by calpain determines platelet microRNA levels and function in diabetes.
25344690 2014 Common variants associated with general and MMR vaccine-related febrile seizures.
24705354 2014 The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23940116 2013 hGAAP promotes cell adhesion and migration via the stimulation of store-operated Ca2+ entry and calpain 2.
23889979 2013 Hypoxia-triggered m-calpain activation evokes endoplasmic reticulum stress and neuropathogenesis in a transgenic mouse model of Alzheimer's disease.
23733271 2013 Calpains are required for invasive and metastatic potentials of human HCC cells.
23538341 2013 Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia.
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