Tchem CTRB1 Chymotrypsinogen B

Protein Summary

Description

This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This gene is located adjacent to a related chymotrypsinogen gene. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• P17538

Gene Name

• CTRB1

Ensembl ID

• ENST00000361017
• ENSP00000354294
• ENSG00000168925

Symbol

• CTRB
• CTRB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
pathway	0.83
drug	0.75
cell type or tissue	0.59
tissue	0.58
gene perturbation	0.53

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Chymotrypsinogen B

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Chymotrypsinogen B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.01   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 186   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.01   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 41

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1