Property Summary

NCBI Gene PubMed Count 87
Grant Count 144
R01 Count 77
Funding $10,477,673.69
PubMed Score 246.90
PubTator Score 327.19

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (18)

Disease log2 FC p
gastric cancer -1.900 0.040
Multiple myeloma 1.021 0.012
ependymoma 1.400 0.012
psoriasis -1.700 0.000
atypical teratoid / rhabdoid tumor 1.400 0.001
glioblastoma 1.500 0.002
medulloblastoma 1.500 0.008
medulloblastoma, large-cell 1.300 0.000
pancreatic ductal adenocarcinoma liver m... 1.452 0.008
non-small cell lung cancer -1.392 0.000
lung cancer -1.300 0.000
active Crohn's disease -1.413 0.023
subependymal giant cell astrocytoma -1.321 0.013
COPD -1.600 0.004
Polycystic Ovary Syndrome -1.033 0.013
lung carcinoma -1.100 0.000
ovarian cancer 1.200 0.007
Gaucher disease type 3 1.600 0.005

Synonym

Accession P17535 Q53EK9
Symbols AP-1

Gene

PANTHER Protein Class (1)

PDB

3U86  

Gene RIF (47)

PMID Text
26747248 CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.
26305372 recombinant SERPINE2 induced a clear inhibition of MMP-13 expression in IL-1alpha-stimulated chondrocytes. This inhibitory effect is likely regulated through a pathway involving ERK 1/2, NF-kappaB and AP-1
25906693 miR-494 is a novel regulator of HNPC apoptosis induced by TNF-alpha
25788572 JunD activates miR-29b by enhancing its transcription and processing, which contribute to the inhibitory effect of JunD
24658685 Cells in contact with basement membrane undergo transient oscillations between two molecular states defined by their TGFBR3- JUND expression.
24551192 HIV-1 Vpu-expressing U937 monocytes coculture with LX2 stellate cells to activate release of transforming growth factor beta to culture supernatant, which correlates with increased activity of the AP-1 transcription factor
24140207 BAG3 stabilized JunD mRNA.
24038602 Binding of specific AP-1 factors, we found JunD associated with the LILRB1 distal promoter.
23942796 Jun proteins (pc-Jun and JunD) influence carcinogenesis and tumour progression, suggesting a significant role as prognostic predictors in human ovarian carcinoma.
23376981 This genotype-phenotype correlation study confirmed the lack of direct genotype-phenotype correlations. However, patients with mutations affecting the JunD interacting domain had a higher risk of death secondary to a MEN1 tumor
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AA Sequence

METPFYGDEALSGLGGGASGSGGSFASPGRLFPGAPPTAAAGSMMKKDALTLSLSEQVAAALKPAAAPPP      1 - 70
TPLRADGAPSAAPPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTSSQFLYPKVAASEEQEFAEGF     71 - 140
VKALEDLHKQNQLGAGAAAAAAAAAAGGPSGTATGSAPPGELAPAAAAPEAPVYANLSSYAGGAGGAGGA    141 - 210
ATVAFAAEPVPFPPPPPPGALGPPRLAALKDEPQTVPDVPSFGESPPLSPIDMDTQERIKAERKRLRNRI    211 - 280
AASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY       281 - 347
//

Text Mined References (92)

PMID Year Title
26747248 2016 CARMA1- and MyD88-dependent activation of Jun/ATF-type AP-1 complexes is a hallmark of ABC diffuse large B-cell lymphomas.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
26305372 2015 SERPINE2 Inhibits IL-1?-Induced MMP-13 Expression in Human Chondrocytes: Involvement of ERK/NF-?B/AP-1 Pathways.
25906693 2015 MicroRNA-494 inhibition protects nucleus pulposus cells from TNF-?-induced apoptosis by targeting JunD.
25788572 2015 JunD enhances miR-29b levels transcriptionally and posttranscriptionally to inhibit proliferation of intestinal epithelial cells.
25609649 2015 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
24658685 2014 A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies.
24647988 2014 Targeting androgen receptor and JunD interaction for prevention of prostate cancer progression.
24140207 2013 BAG3 is upregulated by c-Jun and stabilizes JunD.
24038602 2014 The AP-1 transcription factor JunD activates the leukocyte immunoglobulin-like receptor 1 distal promoter.
More...