Tchem AKR1C4 Aldo-keto reductase family 1 member C4

Protein Summary

Description

Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P17516
• Q5T6A3
• Q8WW84
• Q9NS54

Gene Name

• AKR1C4

Ensembl ID

• ENST00000263126
• ENSP00000263126
• ENSG00000198610
• ENST00000380448
• ENSP00000369814

Symbol

• CHDR
• C11
• CDR
• DD4
• CHDR
• DD-4
• HAKRA
• 3-alpha-HSD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.97
molecular function	0.91
cell type or tissue	0.77
chemical	0.75
biological process	0.73

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C4

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Aldo-keto Reductase Family 1 Member C4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.37   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 271   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 124.37   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0