Property Summary

NCBI Gene PubMed Count 448
PubMed Score 3888.36
PubTator Score 1729.40

Knowledge Summary


No data available


  Disease Sources (7)

Disease Target Count P-value
juvenile dermatomyositis 1189 2.15457373941587E-10
lung carcinoma 2844 2.15470953664668E-8
Duchenne muscular dystrophy 602 2.35158367524363E-8
malignant mesothelioma 3163 1.25574669873911E-7
pituitary cancer 1972 3.88693498730447E-7
group 4 medulloblastoma 1875 4.54769841697314E-7
ovarian cancer 8492 4.60876236697793E-7
lung adenocarcinoma 2714 7.18374231435841E-6
medulloblastoma, large-cell 6234 7.94749752319743E-6
lung cancer 4473 5.75175687838796E-4
autosomal dominant Emery-Dreifuss muscular dystrophy 499 8.30309927979019E-4
Breast cancer 3099 9.86242406581516E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00205443451469732
dermatomyositis 967 0.00216648530080675
active ulcerative colitis 477 0.00380566840254218
osteosarcoma 7933 0.00398909191127145
pancreatic cancer 2300 0.00433817724361002
Down syndrome 548 0.00505607876045531
primary pancreatic ductal adenocarcinoma 1271 0.00710800750385349
nasopharyngeal carcinoma 1056 0.00801831049282945
breast carcinoma 1614 0.0104596901348014
Becker muscular dystrophy 187 0.0123437742567709
gastric carcinoma 832 0.0134001633371126
primitive neuroectodermal tumor 3031 0.0136141538620783
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0219664770826566
acute quadriplegic myopathy 1157 0.0224779383302296
diabetes mellitus 1663 0.030032991386628
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0404856643322531
invasive ductal carcinoma 2950 0.043614535492146
aldosterone-producing adenoma 664 0.0498187448242833
Disease Target Count Z-score Confidence
Heart disease 279 5.601 2.8
Disease Target Count Z-score Confidence
Palmoplantar keratosis 36 3.648 1.8
Cataract 104 0.0 4.0
Hypotrichosis 29 0.0 4.0



Accession P17302 B2R5U9 Q6FHU1 Q9Y5I8
Symbols HSS


PANTHER Protein Class (2)



  Ortholog (14)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Pig OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

Gene RIF (391)

26902399 high glucose disassociated interactions between Cx43 and tight junctions, and then increased airway epithelial transepithelial electrical resistance and permeability by down-regulation of Cx43 in human airway epithelial cells.
26869446 Increased membrane permeability induced by linoleic acid is mediated by an intracellular signaling pathway activated by GPR40 that leads to an increase in membrane levels of Cx43 phosphorylated at serine 373 via Akt.
26823747 Report expression of connexin 43 in ovarian cancer cells in G1/S phase.
26784020 Connexin 43 significantly regulates osteogenic differentiation in the cells from posterior longitudinal ligament by altering the activity of ERK, and subsequently causing the modification of Runx2.
26586821 The results of this study showed that in the olfactory bulb, connexin 43 hemichannel function is promoted by neuronal activity and modulates neuronal network slow oscillations.
26543049 Stage of labour effected uterine expression of phosphorylated form
26517241 Cx43 expressed by mesenchymal stem cells induces apoptosis on leukemia cells.
26491675 AR pathway plays an important role in regulation of CX43 expression in prostate cancer cells. AR may be the upstream signal of CX43.
26481195 Cx43-Hsc70 interaction regulates cell cycle G1/S progression through a novel mechanism by which Cx43-Hsc70 interaction prevents the nuclear accumulation of p27 through controlling the nuclear translocation of cyclin D1-CDK4-p27 complex.
26450928 we are the first to identify that miR-381 suppresses C/EBPalpha-dependent Cx43 expression in breast cancer cells. The miR-381-C/EBPalpha-Cx43 axis might be a useful diagnostic and therapeutic target of metastatic breast cancer

AA Sequence

HELQPLAIVDQRPSSRASSRASSRPRPDDLEI                                          351 - 382

Text Mined References (461)

PMID Year Title
26902399 2016 High glucose induces dysfunction of airway epithelial barrier through down-regulation of connexin 43.
26869446 2016 Linoleic acid permeabilizes gastric epithelial cells by increasing connexin 43 levels in the cell membrane via a GPR40- and Akt-dependent mechanism.
26823747 2015 Roles of Cx43 and AKAP95 in ovarian cancer tissues in G1/S phase.
26784020 2016 Connexin 43 Affects Osteogenic Differentiation of the Posterior Longitudinal Ligament Cells via Regulation of ERK Activity by Stabilizing Runx2 in Ossification.
26586821 2015 Astroglial Connexin 43 Hemichannels Modulate Olfactory Bulb Slow Oscillations.
26543049 2016 Modelling maternal obesity: the effects of a chronic high-fat, high-cholesterol diet on uterine expression of contractile-associated proteins and ex vivo contractile activity during labour in the rat.
26517241 2015 Increased expression of CX43 on stromal cells promotes leukemia apoptosis.
26491675 2015 AR Pathway Is Involved in the Regulation of CX43 in Prostate Cancer.
26481195 2015 Interaction of Cx43 with Hsc70 regulates G1/S transition through CDK inhibitor p27.
26450928 2015 miR-381 suppresses C/EBP?-dependent Cx43 expression in breast cancer cells.