Property Summary

NCBI Gene PubMed Count 668
PubMed Score 212.15
PubTator Score 1382.62

Knowledge Summary

Patent (177,730)

TINX Plot

  Disease Sources (4)

Disease Target Count P-value
psoriasis 6685 7.48774139482065E-9
Breast cancer 3099 3.16043618292378E-8
lung carcinoma 2844 8.14044551606959E-8
group 4 medulloblastoma 1875 8.76721276954196E-7
ovarian cancer 8492 9.590415600514E-6
tuberculosis and treatment for 3 months 327 1.61641528807723E-5
medulloblastoma, large-cell 6234 4.86464583737228E-5
atypical teratoid / rhabdoid tumor 4369 8.7724641318686E-5
intraductal papillary-mucinous carcinoma (IPMC) 2988 2.48096714788653E-4
lung cancer 4473 2.73059689123652E-4
invasive ductal carcinoma 2950 3.95852617584318E-4
lung adenocarcinoma 2714 0.00300436159593278
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00366914389421506
glioblastoma 5572 0.00458325808306244
mucosa-associated lymphoid tissue lymphoma 480 0.0064478865626482
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.00677347835448162
Common variable immunodeficiency 98 0.0072149064723274
adrenocortical carcinoma 1427 0.0102554333275176
aldosterone-producing adenoma 664 0.0224018399899959
primitive neuroectodermal tumor 3031 0.0404704980559828
spina bifida 1064 0.0458977361311681
astrocytoma 1493 0.0498690860773271
Disease Target Count Z-score Confidence
Heart disease 279 0.0 2.0
Disease Target Count Z-score Confidence
Cancer 2346 3.536 1.8

Expression

Synonym

Accession P17252 B5BU22 Q15137 Q32M72 Q96RE4 PKC-A
Symbols AAG6
PKCA
PRKACA
PKC-alpha

Gene

PDB

2ELI   3IW4   4DNL   4RA4  

  Ortholog (9)

  TechDev Info (1)

Gary Johnson Kinome profile via MIB/MS Technology

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
652206 other 0 / 0 / 0 ML-187 activity in a kinase panel for Extended probe characterization for beta-cell apoptosis Measured in Biochemical System

Gene RIF (427)

PMID Text
26826385 High P-PKCalpha expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCalpha might act as an indicator of gastric cancer progression.
26769967 Prolonged membrane association/activation of PKCalpha is seen in self-renewing epithelium of the intestine, cervix, and skin.
26676968 RNA sequencing identified a novel ATPase, Ca2+ transporting, plasma membrane 4(ATP2B4)-protein kinase C-alpha (PRKCA) fusion transcript.
26671581 This study showed that SLC44A1-PRKCA fusion seems to be a specific characteristic of Papillary glioneuronal tumors with a high diagnostic value.
26662512 Kinocilium is essential for proper localization of Lgn, as well as Gai and aPKC, suggesting that cilium function plays a role in positioning of apical proteins critical for hearing.
26657401 Data show that bisindolylmaleimides (BIMs) Ro 31-8220 also blocks activity of the solute carrier organic cation transporter 1 (OCT1), involved in uptake of marketed drugs in the liver, in a protein kinase C (PKC)-independent manner.
26542395 PKCalpha is coupled to ATP-stimulated TMEM16A activation in biliary epithelial cells.
26398575 InB may exhibit growth-inhibitory activity through the activation of PKCalpha, followed by an increase in NFAT transactivation ability.
26350262 PKCalpha Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance
26304124 lipids mediate post-transcriptional regulation of HAMP through PKC- and HuR-dependent mechanisms
More...

AA Sequence

MADVFPGNDSTASQDVANRFARKGALRQKNVHEVKDHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVC      1 - 70
CFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVH     71 - 140
KQCVINVPSLCGMDHTEKRGRIYLKAEVADEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQ    141 - 210
KTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQ    211 - 280
EEGEYYNVPIPEGDEEGNMELRQKFEKAKLGPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSF    281 - 350
GKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYV    351 - 420
NGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMM    421 - 490
DGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKS    491 - 560
LSKEAVSVCKGLMTKHPAKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFF    561 - 630
TRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV                                631 - 672
//

Text Mined References (692)

PMID Year Title
26826385 2016 Cobalt chloride-mediated protein kinase C? (PKC?) phosphorylation induces hypoxia-inducible factor 1? (HIF1?) in the nucleus of gastric cancer cell.
26769967 2016 Protein Kinase C? (PKC?) Is Resistant to Long Term Desensitization/Down-regulation by Prolonged Diacylglycerol Stimulation.
26676968 2016 Pigment-Synthesizing Melanocytic Neoplasm With Protein Kinase C Alpha (PRKCA) Fusion.
26671581 2015 Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion.
26662512 2016 The GPSM2/LGN GoLoco motifs are essential for hearing.
26657401 2015 Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220.
26542395 2016 PKC? regulates TMEM16A-mediated Cl? secretion in human biliary cells.
26398575 2015 Protein kinase C?-mediated cytotoxic activity of ineupatorolide B from Inula cappa DC. in HeLa cells.
26350262 2016 PKC? Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance.
26304124 2015 Saturated fatty acids induce post-transcriptional regulation of HAMP mRNA via AU-rich element-binding protein, human antigen R (HuR).
More...