| Tclin | Interferon alpha/beta receptor 1 |
Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
Comments
Property Summary
| Ligand Count | 5 |
| NCBI Gene PubMed Count | 138 |
| PubMed Score | 449.26 |
| PubTator Score | 192.62 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Virus Diseases | 2 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Depressive Symptoms | 28 |
| Drug-induced depressive state | 14 |
| Disease | Target Count |
|---|---|
| Chronic hepatitis C | 12 |
| Chronic type B viral hepatitis | 2 |
| Relapsing remitting multiple sclerosis | 14 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 3.9e-14 |
| hepatocellular carcinoma | 547 | 1.1e-04 |
| osteosarcoma | 7950 | 1.8e-04 |
| psoriasis | 6694 | 5.6e-04 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 7.9e-04 |
| medulloblastoma, large-cell | 6241 | 1.3e-03 |
| tuberculosis and treatment for 6 months | 409 | 1.6e-03 |
| pancreatic cancer | 2398 | 1.6e-03 |
| pancreatic carcinoma | 562 | 1.6e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Multiple Sclerosis | 540 | 4.024 | 2.0 |
| Hepatitis C | 94 | 3.511 | 1.8 |
| Hypersensitivity reaction type II disease | 253 | 3.481 | 1.7 |
| Influenza | 142 | 3.422 | 1.7 |
| Cancer | 2499 | 3.243 | 1.6 |
| Hepatitis | 67 | 3.19 | 1.6 |
| Septicemic plague | 1 | 3.177 | 1.6 |
| Encephalitis | 64 | 3.145 | 1.6 |
| Down syndrome | 499 | 3.055 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| hepatocellular carcinoma | 1.100 | 1.1e-04 |
| medulloblastoma, large-cell | -1.200 | 1.3e-03 |
| osteosarcoma | -1.405 | 1.8e-04 |
| ovarian cancer | -2.000 | 3.9e-14 |
| pancreatic cancer | 1.500 | 1.6e-03 |
| pancreatic carcinoma | 1.500 | 1.6e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.999 | 7.9e-04 |
| psoriasis | 1.100 | 5.6e-04 |
| tuberculosis and treatment for 6 months | -1.300 | 1.6e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MMVVLLGATTLVLVAVAPWVLSAAAGGKNLKSPQKVEVDIIDDNFILRWNRSDESVGNVTFSFDYQKTGM 1 - 70 DNWIKLSGCQNITSTKCNFSSLKLNVYEEIKLRIRAEKENTSSWYEVDSFTPFRKAQIGPPEVHLEAEDK 71 - 140 AIVIHISPGTKDSVMWALDGLSFTYSLVIWKNSSGVEERIENIYSRHKIYKLSPETTYCLKVKAALLTSW 141 - 210 KIGVYSPVHCIKTTVENELPPPENIEVSVQNQNYVLKWDYTYANMTFQVQWLHAFLKRNPGNHLYKWKQI 211 - 280 PDCENVKTTQCVFPQNVFQKGIYLLRVQASDGNNTSFWSEEIKFDTEIQAFLLPPVFNIRSLSDSFHIYI 281 - 350 GAPKQSGNTPVIQDYPLIYEIIFWENTSNAERKIIEKKTDVTVPNLKPLTVYCVKARAHTMDEKLNKSSV 351 - 420 FSDAVCEKTKPGNTSKIWLIVGICIALFALPFVIYAAKVFLRCINYVFFPSLKPSSSIDEYFSEQPLKNL 421 - 490 LLSTSEEQIEKCFIIENISTIATVEETNQTDEDHKKYSSQTSQDSGNYSNEDESESKTSEELQQDFV 491 - 557 //
