Tbio ZKSCAN1 Zinc finger protein with KRAB and SCAN domains 1

Protein Summary

Description

May be involved in transcriptional regulation. This gene encodes a member of the Kruppel C2H2-type zinc-finger family of proteins. This encoded protein may function as a transcription factor that regulates the expression of GABA type-A receptors in the brain. Transcripts from this gene have been shown to form stable and abundant circular RNAs. Elevated expression of this gene has been observed in gastric cancer and the encoded protein may stimulate migration and invasion of human gastric cancer cells. [provided by RefSeq, Oct 2016]

Uniprot Accession IDs

• P17029
• A4D294
• P52745
• Q2M1U1
• Q8TBW5
• Q8TEK7

Gene Name

• ZKSCAN1

Ensembl ID

• ENST00000324306
• ENSP00000323148
• ENSG00000106261

Symbol

• KOX18
• ZNF139
• ZNF36
• KOX18
• ZNF36
• PHZ-37
• ZNF139
• ZSCAN33

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
disease perturbation	0.9
microRNA	0.9
protein domain	0.85
transcription factor binding site profile	0.79

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 143   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0