| Tbio | Natriuretic peptides B |
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
Comments
| Disease | Target Count |
|---|---|
| Congenital Heart Defects | 58 |
| Hypertensive disease | 292 |
| Pulmonary hypertension | 86 |
| Disease | Target Count | P-value |
|---|---|---|
| cystic fibrosis | 1696 | 2.3e-07 |
| permanent atrial fibrillation | 45 | 1.6e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Heart disease | 306 | 6.578 | 3.3 |
| Bulimia nervosa | 14 | 4.388 | 2.2 |
| Cerebrovascular disease | 238 | 3.962 | 2.0 |
| diabetes mellitus | 1728 | 3.902 | 2.0 |
| Central sleep apnea | 11 | 3.856 | 1.9 |
| Kidney Failure | 111 | 3.796 | 1.9 |
| Pulmonary embolism | 55 | 3.539 | 1.8 |
| Anorexia nervosa | 80 | 3.243 | 1.6 |
| Lung disease | 142 | 3.164 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| cystic fibrosis | -2.762 | 2.3e-07 |
| permanent atrial fibrillation | 1.500 | 1.6e-02 |
