| Tbio | Natriuretic peptides B |
Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| cystic fibrosis | 1670 | 2.34653178512912E-7 |
| permanent atrial fibrillation | 44 | 0.0160161945941738 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Heart disease | 279 | 6.497 | 3.2 |
| Hypertension | 293 | 5.135 | 2.6 |
| Bulimia nervosa | 15 | 4.42 | 2.2 |
| Cerebrovascular disease | 231 | 3.966 | 2.0 |
| diabetes mellitus | 1663 | 3.872 | 1.9 |
| Central sleep apnea | 12 | 3.769 | 1.9 |
| Kidney failure | 41 | 3.762 | 1.9 |
| Pulmonary Embolism | 45 | 3.51 | 1.8 |
| Anorexia nervosa | 59 | 3.268 | 1.6 |
| Lung disease | 136 | 3.019 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| permanent atrial fibrillation | 1.500 | 0.016 |
| cystic fibrosis | -2.762 | 0.000 |
| Species | Source |
|---|---|
| Chimp | OMA EggNOG |
| Mouse | OMA EggNOG Inparanoid |
| Rat | OMA EggNOG Inparanoid |
| Dog | OMA EggNOG Inparanoid |
| Cow | OMA EggNOG Inparanoid |
| Platypus | OMA EggNOG |
| PMID | Text |
|---|---|
| 27328498 | Umbilical arterial NTproBNP levels were significantly higher in the pre-eclampsia, fetal growth restriction, preterm birth, and fetal distress groups than in the control group. |
| 27328493 | NTproBNP was decreased in the umbilical cord blood of fetuses with meconium stained amniotic fluid compared to controls. |
| 27085779 | Data suggest that low serum levels of NT-proBNP are an independent risk factor/biomarker for diagnosis of NAFLD; low serum levels of NT-proBNP correlate with presence of elevated fat accumulation in liver (in a multi-ethnic, cross-sectional study). |
| 27077910 | Data suggest testing for aminoterminal pro-B-type natriuretic peptide (NT-proBNP) should be performed in the hospitalized very elderly, because of the very high prevalence of underlying heart failure (HF) and its impact on in-hospital mortality. |
| 26957276 | BNP levels can be used as a clinical indicator to predict short-term prognosis in ST-elevation myocardial infarction patients. |
| 26949703 | Combined with hydration, exogenous brain natriuretic peptide administration before contrast media effectively decreases contrast-induced nephropathy incidence in chronic kidney disease patients |
| 26868212 | Obstructive CAD causing myocardial ischemia is associated with increased levels of NT-proBNP. |
| 26852688 | Recombinant human BNP attenuates trauma/haemorrhagic shock-induced acute lung injury by inhibiting oxidative stress and the NF-kappaB-dependent inflammatory/MMP-9 signaling pathway. |
| 26845306 | In cirrhotic patients, pre-liver transplant BNP serum level was an independent predictor of post-LT ICU mortality. |
| 26801306 | BNP levels rose after paroxysmal supraventricular tachycardia and continued to rise after the termination. |
| More... |
| PMID | Year | Title |
|---|---|---|
| 27328498 | 2016 | Umbilical arterial N-terminal pro-B-type natriuretic peptide levels in preeclampsia, fetal growth restriction, preterm birth and fetal distress. |
| 27328493 | 2016 | N terminal-pro brain natriuretic peptide in fetal umbilical cord meconium-stained amniotic fluid: a prospective case control study. |
| 27085779 | 2016 | Computerized tomography measured liver fat is associated with low levels of N-terminal pro-brain natriuretic protein (NT-proBNP). Multi-Ethnic Study of Atherosclerosis. |
| 27077910 | 2016 | NT-proBNP and Its Correlation with In-Hospital Mortality in the Very Elderly without an Admission Diagnosis of Heart Failure. |
| 26957276 | 2016 | Relationship between B-type natriuretic peptide and short-term prognosis in non-diabetic patients with ST-segment elevation myocardial infarction. |
| 26949703 | 2016 | Recombinant Brain Natriuretic Peptide for the Prevention of Contrast-Induced Nephropathy in Patients with Chronic Kidney Disease Undergoing Nonemergent Percutaneous Coronary Intervention or Coronary Angiography: A Randomized Controlled Trial. |
| 26868212 | 2016 | Effect of Coronary Atherosclerosis and Myocardial Ischemia on Plasma Levels of High-Sensitivity Troponin T and NT-proBNP in Patients With Stable Angina. |
| 26852688 | 2015 | Recombinant human brain natriuretic peptide attenuates trauma-/haemorrhagic shock-induced acute lung injury through inhibiting oxidative stress and the NF-?B-dependent inflammatory/MMP-9 pathway. |
| 26845306 | 2016 | Prognostic Value of Preoperative Brain Natriuretic Peptide Serum Levels in Liver Transplantation. |
| 26801306 | 2016 | Responses of cardiac natriuretic peptides after paroxysmal supraventricular tachycardia: ANP surges faster than BNP and CNP. |
| More... |
