Tchem ALOX15 Arachidonate 15-lipoxygenase

Protein Summary

Description

Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12-hydroperoxyeicosatetraenoic acid/12-HPETE and 15-hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function through regulation of the peroxisome proliferator activated receptor signaling pathway. Finally, it is also involved in the cellular response to IL13/interleukin-13. In addition to its role in the immune and inflammatory responses, may play a role in epithelial wound healing in the cornea maybe through production of lipoxin A4. May also play a role in endoplasmic reticulum stress response and the regulation of bone mass. This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and other molecules. The encoded enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

Uniprot Accession IDs

• P16050
• A8K2P4
• B7ZA11
• Q8N6R7
• Q99657
• 15-LOX

Gene Name

• ALOX15

Ensembl ID

• ENST00000293761
• ENSP00000293761
• ENSG00000161905
• ENST00000570836
• ENSP00000458832
• ENST00000574640
• ENSP00000460483

Symbol

• LOG15
• LOG15
• 12-LOX
• 15-LOX
• 15-LOX-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.96
protein domain	0.92
biological term	0.91
molecular function	0.91
chemical	0.68

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Oxygenase / Arachidonate 15-lipoxygenase

DTO Classes

Protein / Enzyme / Oxidoreductase / Oxygenase / Arachidonate 15-lipoxygenase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 675.04   (req: < 5)

Gene RIFs: 172   (req: <= 3)

Antibodies: 302   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 675.04   (req: >= 5)

Gene RIFs: 172   (req: > 3)

Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 171

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2