Property Summary

NCBI Gene PubMed Count 358
PubMed Score 1043.85
PubTator Score 954.68

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
lung carcinoma 2844 1.63198188267091E-28
ovarian cancer 8492 6.83372267891279E-10
juvenile dermatomyositis 1189 6.04551565502882E-8
posterior fossa group A ependymoma 1511 7.59060615947219E-8
malignant mesothelioma 3163 4.8070987792888E-7
Duchenne muscular dystrophy 602 1.17038218532693E-6
atypical teratoid / rhabdoid tumor 4369 1.39245340799188E-6
glioblastoma 5572 1.90523844905383E-6
pilocytic astrocytoma 3086 5.43789989485981E-6
pediatric high grade glioma 2712 7.5076037540045E-6
pituitary cancer 1972 7.77377191995681E-6
lung cancer 4473 5.58157243220674E-5
primary pancreatic ductal adenocarcinoma 1271 1.79594801908927E-4
fascioscapulohumeral muscular dystrophy 100 1.91238287101799E-4
pancreatic cancer 2300 2.0589985283347E-4
Atopic dermatitis 944 0.00115217624887496
medulloblastoma 1524 0.00139419838080264
limb girdle muscular dystrophy 2A 156 0.00183394772708268
invasive ductal carcinoma 2950 0.00314423497408664
primitive neuroectodermal tumor 3031 0.00322539511961898
ulcerative colitis 2087 0.00345995721472737
autosomal dominant Emery-Dreifuss muscular dystrophy 499 0.00412109146720508
acute quadriplegic myopathy 1157 0.00509143025322959
gastric carcinoma 832 0.00685093012150468
inflammatory breast cancer 404 0.00999491254001326
intraductal papillary-mucinous adenoma (IPMA) 2956 0.0136654013382625
fibroadenoma 557 0.0136916149256343
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.0182392691220678
subependymal giant cell astrocytoma 2287 0.0204894306346402
non primary Sjogren syndrome sicca 840 0.031362019925471
Becker muscular dystrophy 187 0.0439288427693556
Disease Target Count Z-score Confidence
Connective tissue disease 59 0.0 1.0



Accession P16035 Q16121 Q93006 Q9UDF7
Symbols DDC8



4ILW   1GXD   1BR9   2TMP  

  Ortholog (11)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Horse OMA EggNOG
Cow OMA EggNOG Inparanoid
Opossum OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
C. elegans OMA EggNOG

Gene RIF (334)

26978018 The invasive potential of CSCC has been established to be substantially influenced by the increased expression of MMP-9 and uPA and by the decreased expression of TIMP-2, as well as to a lesser extent by a change in MMP-2 expression
26823777 Pathogenesis and progression of nasal polyps is closely related with elevated MMP-9 and suppressed TIMP-2 expression
26606754 This study shows that urinary [TIMP-2]*[IGFBP7] has a good diagnostic performance in predicting adverse outcomes in neonatal and pediatric AKI of heterogeneous etiology.
26556867 our results demonstrate that TIMP-2 stimulates lung adenocarcinoma cell proliferation
26551785 showed a significant association between the variants of MMP-2 and TIMP-2 promoters and spontaneous intracerebral hemorrhage
26539028 TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients.
26331622 TIMP-2 interaction with MT1-MMP provides tumor cells with either pro- or anti-apoptotic signaling depending on the extracellular environment and apoptotic stimulus.
26329758 TIMP2 is elevated in patients with non-alcoholic fatty liver disease.
26278569 MiR-761 directly targeted ING4 and TIMP2.
26268417 The expression levels MMP-9, TIMP-1, and TIMP-2 in both marrow plasma and culture supernatants were significantly higher in MM patients than controls.

AA Sequence

KQEFLDIEDP                                                                211 - 220

Text Mined References (360)

PMID Year Title
26978018 [Matrix metalloproteinases 2 and 9, their endogenous regulators, and angiotensin-converting enzyme in cervical squamous cell carcinoma].
26823777 2015 Expression of MMP-9/TIMP-2 in nasal polyps and its functional implications.
26606754 2015 Urinary Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) • Insulin-Like Growth Factor-Binding Protein 7 (IGFBP7) Predicts Adverse Outcome in Pediatric Acute Kidney Injury.
26556867 2015 Growth-stimulatory activity of TIMP-2 is mediated through c-Src activation followed by activation of FAK, PI3-kinase/AKT, and ERK1/2 independent of MMP inhibition in lung adenocarcinoma cells.
26551785 2015 Polymorphisms in the Promoters of the MMP-2 and TIMP-2 Genes Are Associated with Spontaneous Deep Intracerebral Hemorrhage in the Taiwan Population.
26539028 2015 TIMP1, TIMP2, and TIMP4 are increased in aqueous humor from primary open angle glaucoma patients.
26331622 2015 TIMP-2 Interaction with MT1-MMP Activates the AKT Pathway and Protects Tumor Cells from Apoptosis.
26329758 2015 Tissue Inhibitors of Metalloproteinase-1 and 2 and Obesity Related Non-Alcoholic Fatty Liver Disease: Is There a Relationship.
26278569 2015 MiR-761 Promotes Progression and Metastasis of Non-Small Cell Lung Cancer by Targeting ING4 and TIMP2.
26268417 2016 Increased expression of metalloproteinase-2 and -9 (MMP-2, MMP-9), tissue inhibitor of metalloproteinase-1 and -2 (TIMP-1, TIMP-2), and EMMPRIN (CD147) in multiple myeloma.