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Tchem
MUC1
Mucin-1

Protein Summary
Description
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity. This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337604
  • ENSP00000338983
  • ENSG00000185499
  • ENST00000342482
  • ENSP00000342814
  • ENST00000343256
  • ENSP00000339690
  • ENST00000368389
  • ENSP00000357374
  • ENST00000368390
  • ENSP00000357375
  • ENST00000368392
  • ENSP00000357377
  • ENST00000368393
  • ENSP00000357378
  • ENST00000368396
  • ENSP00000357381
  • ENST00000368398
  • ENSP00000357383

Symbol
  • PUM
  • EMA
  • MCD
  • PEM
  • PUM
  • KL-6
  • MAM6
  • MCKD
  • PEMT
  • CD227
  • H23AG
  • MCKD1
  • MUC-1
  • ADMCKD
  • ADMCKD1
  • CA 15-3
  • MUC-1/X
  • MUC1/ZD
  • MUC-1/SEC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
hub protein
0.94
transcription factor binding site profile
0.89
biological term
0.86
PubMedID
0.86


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5211.25   (req: < 5)
Gene RIFs: 850   (req: <= 3)
Antibodies: 4111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5211.25   (req: >= 5)
Gene RIFs: 850   (req: > 3)
Antibodies: 4111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0