Tchem PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

Protein Summary

Description

Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM (By similarity). Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, and encoded by one gene. The gamma subunit also includes the skeletal muscle and hepatic isoforms, and the hepatic isoform is encoded by this gene. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9C, also known as autosomal liver glycogenosis. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]

Uniprot Accession IDs

• P15735
• A8K0C7
• B4DEB7
• E9PEU3
• P11800
• PHK-gamma-LT

Gene Name

• PHKG2

Ensembl ID

• ENST00000424889
• ENSP00000388571
• ENSG00000156873
• ENST00000563588
• ENSP00000455607

Symbol

• GSD9C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.96
protein domain	0.92
kinase perturbation	0.81
disease perturbation	0.74
histone modification site profile	0.72

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Phk Family / Phosphorylase B Kinase Gamma Catalytic Chain, Liver/testis Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.61   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 338   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.61   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 6

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1