CYP11B1
Cytochrome P450 11B1, mitochondrial
Protein Summary
Has steroid 11-beta-hydroxylase activity. In addition to this activity, the 18 or 19-hydroxylation of steroids and the aromatization of androstendione to estrone have also been ascribed to cytochrome P450 XIB. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane and is involved in the conversion of progesterone to cortisol in the adrenal cortex. Mutations in this gene cause congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency. Transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]
- ENST00000292427
- ENSP00000292427
- ENSG00000160882
- ENST00000517471
- ENSP00000428043
- S11BH
- FHI
- CPN1
- CYP11B
- P450C11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.93 | ||
drug | 0.7 | ||
pathway | 0.67 | ||
disease | 0.65 | ||
biological term | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 573.93 (req: < 5)
Gene RIFs: 82 (req: <= 3)
Antibodies: 211 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 573.93 (req: >= 5)
Gene RIFs: 82 (req: > 3)
Antibodies: 211 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 753
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6