Property Summary

NCBI Gene PubMed Count 62
PubMed Score 132.81
PubTator Score 147.68

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (6)

Disease Target Count
Chemotherapy-induced neutropenia 3
Disease Target Count P-value
psoriasis 6685 2.62516744386481E-81
lung carcinoma 2844 1.9812319034689E-27
malignant mesothelioma 3163 8.7300615524544E-9
tuberculosis and treatment for 6 months 686 3.63392807437994E-6
pilocytic astrocytoma 3086 3.12236752015592E-5
osteosarcoma 7933 2.94898594019021E-4
lung cancer 4473 3.97248336243268E-4
medulloblastoma, large-cell 6234 0.00343335761439554
subependymal giant cell astrocytoma 2287 0.00460180601653558
cutaneous lupus erythematosus 1056 0.013758153164878
glioblastoma 5572 0.0353534026157031
interstitial cystitis 2299 0.0362916852206342

Expression

  Differential Expression (12)

Disease log2 FC p
malignant mesothelioma 4.900 0.000
cutaneous lupus erythematosus 1.200 0.014
osteosarcoma -2.307 0.000
glioblastoma 1.400 0.035
medulloblastoma, large-cell -1.100 0.003
tuberculosis and treatment for 6 months -1.600 0.000
lung cancer -1.300 0.000
interstitial cystitis 1.300 0.036
pilocytic astrocytoma 1.300 0.000
subependymal giant cell astrocytoma 1.813 0.005
lung carcinoma -2.000 0.000
psoriasis 1.300 0.000

Synonym

Accession P15509 A7J003 A8KAM1 B4DW68 J3JS76 J3JS77 O00207 Q14429 Q14430 Q14431 Q16564 GM-CSF-R-alpha
Symbols GMR
CD116
CSF2R
SMDP4
CDw116
CSF2RX
CSF2RY
GMCSFR
CSF2RAX
CSF2RAY
GM-CSF-R-alpha

Gene

PDB

4NKQ   4RS1  

  Ortholog (7)

Species Source
Chimp OMA EggNOG
Mouse OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Cow OMA EggNOG
Pig OMA EggNOG
Opossum OMA EggNOG

 CSPA Cell Line (4)

Gene RIF (29)

PMID Text
25923510 regulatory molecule causative of aortic dissection and intramural haematoma
25425184 Our cohort broadens the spectrum of knowledge about the clinical variability and genotype-phenotype correlations of juvenile PAP, and illustrates the favorable outcome of WLL treatment in severely affected patients
24714374 A possible relationship between dysfunction of the granulocyte-macrophage colony stimulating factor receptor, mapping to the pseudoautosomal X-Y region, may exist in myelodysplastic patients with initially lymphocytic Sweet syndrome.
23933508 Studies indicate the action of GM-CSF can be inhibited by at least two approaches: inhibition by GM-CSF neutralising antibodies, or blockade of GM-CSF binding to its receptor by antibodies against the GM-CSF receptor alpha chain CSF2Ralpha.
23898208 HIV-1 Tat upregulates the expression of colony stimulating factor 2 receptor, alpha subunit (CSF2RA) in human primary T cells
22935703 This study reveals a novel functional role of clathrin-coated structure in GMR signaling and the oncogenesis of JAK2V617F.
22430742 The GM-CSF Ralpha were ubiquitously but not uniformly expressed in neurons throughout the brain and downregulation in brain in patient with alzheimenr disease.
21557945 Identify defective expression and function of CD116 as a distinguishing feature of IBD and implicate an associated defect in innate immune responses toward granulocyte-macrophage colony-stimulating factor.
21056082 67-kDa laminin receptor expression influenced the characteristics of leukemia cells toward an aggressive phenotype and increased the number of granulocyte-macrophage colony-stimulating factor receptors
20078425 Data show that Deletion of the Ig-like domain of GM-CSFRalpha abolished direct GM-CSF binding and decreased growth signalling in the presence of hbetac.
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AA Sequence

MLLLVTSLLLCELPHPAFLLIPEKSDLRTVAPASSLNVRFDSRTMNLSWDCQENTTFSKCFLTDKKNRVV      1 - 70
EPRLSNNECSCTFREICLHEGVTFEVHVNTSQRGFQQKLLYPNSGREGTAAQNFSCFIYNADLMNCTWAR     71 - 140
GPTAPRDVQYFLYIRNSKRRREIRCPYYIQDSGTHVGCHLDNLSGLTSRNYFLVNGTSREIGIQFFDSLL    141 - 210
DTKKIERFNPPSNVTVRCNTTHCLVRWKQPRTYQKLSYLDFQYQLDVHRKNTQPGTENLLINVSGDLENR    211 - 280
YNFPSSEPRAKHSVKIRAADVRILNWSSWSEAIEFGSDDGNLGSVYIYVLLIVGTLVCGIVLGFLFKRFL    281 - 350
RIQRLFPPVPQIKDKLNDNHEVEDEIIWEEFTPEEGKGYREEVLTVKEIT                        351 - 400
//

Text Mined References (64)

PMID Year Title
25923510 2015 Granulocyte macrophage colony-stimulating factor is required for aortic dissection/intramural haematoma.
25425184 2014 Characterization of CSF2RA mutation related juvenile pulmonary alveolar proteinosis.
25416956 2014 A proteome-scale map of the human interactome network.
24714374 2014 Initially lymphocytic Sweet's syndrome in male patients with myelodysplasia: a distinguished clinicopathological entity? Case report and systematic review of the literature.
23933508 2013 GM-CSF as a therapeutic target in inflammatory diseases.
22935703 2012 Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2.
22430742 2012 Distribution of granulocyte-monocyte colony-stimulating factor and its receptor ?-subunit in the adult human brain with specific reference to Alzheimer's disease.
21557945 2011 Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease.
21056082 2011 High expression of 67-kDa laminin receptor relates to the proliferation of leukemia cells and increases expression of GM-CSF receptor.
20078425 2010 The Ig-like domain of human GM-CSF receptor alpha plays a critical role in cytokine binding and receptor activation.
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