Tclin CSF2RA Granulocyte-macrophage colony-stimulating factor receptor subunit alpha

Protein Summary

Description

Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. The protein encoded by this gene is the alpha subunit of the heterodimeric receptor for colony stimulating factor 2, a cytokine which controls the production, differentiation, and function of granulocytes and macrophages. The encoded protein is a member of the cytokine family of receptors. This gene is found in the pseudoautosomal region (PAR) of the X and Y chromosomes. Multiple transcript variants encoding different isoforms have been found for this gene, with some of the isoforms being membrane-bound and others being soluble. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15509
• A7J003
• A8KAM1
• B4DW68
• J3JS76
• J3JS77
• O00207
• Q14429
• Q14430
• Q14431
• Q16564
• GM-CSF-R-alpha

Gene Name

• CSF2RA

Ensembl ID

• ENST00000355432
• ENSP00000347606
• ENSG00000198223
• ENST00000355805
• ENSP00000348058
• ENST00000381500
• ENSP00000370911
• ENST00000381509
• ENSP00000370920
• ENST00000381524
• ENSP00000370935
• ENST00000381529
• ENSP00000370940
• ENST00000417535
• ENSP00000394227
• ENST00000432318
• ENSP00000416437
• ENST00000501036
• ENSP00000440491

Symbol

• CSF2R
• CSF2RY
• GMR
• CD116
• CSF2R
• SMDP4
• CDw116
• CSF2RX
• CSF2RY
• GMCSFR
• CSF2RAX
• CSF2RAY
• alphaGMR
• GM-CSF-R-alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
disease perturbation	0.79
cell type or tissue	0.7
hub protein	0.63
tissue sample	0.63

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Granulocyte-macrophage Colony-stimulating Factor Receptor Subunit Alpha

Protein / Defense/immunity Protein / Granulocyte-macrophage Colony-stimulating Factor Receptor Subunit Alpha

DTO Classes

Protein / Signaling / Cytokine / Granulocyte-macrophage Colony-stimulating Factor Receptor Subunit Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1068.28   (req: < 5)

Gene RIFs: 37   (req: <= 3)

Antibodies: 666   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1068.28   (req: >= 5)

Gene RIFs: 37   (req: > 3)

Antibodies: 666   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1