Property Summary

NCBI Gene PubMed Count 40
PubMed Score 120.72
PubTator Score 59.57

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
lung carcinoma 2844 7.68978836193617E-13
acute quadriplegic myopathy 1157 1.14043077519422E-11
juvenile dermatomyositis 1189 1.51973636131722E-10
chronic lymphosyte leukemia 232 9.31155362984279E-9
tuberculosis 1563 7.04320818420711E-7
malignant mesothelioma 3163 1.10581509459377E-6
pituitary cancer 1972 3.72190952505695E-6
ovarian cancer 8492 1.00815051007657E-5
psoriasis 6685 1.05696146920107E-5
hepatocellular carcinoma 550 2.60683054023733E-5
medulloblastoma, large-cell 6234 3.26864563057553E-5
lung cancer 4473 1.02688206637073E-4
posterior fossa group B ependymoma 1530 1.05331161314911E-4
primitive neuroectodermal tumor 3031 1.10343074181761E-4
pancreatic cancer 2300 2.17687283396507E-4
adrenocortical carcinoma 1427 2.32012595582366E-4
atypical teratoid / rhabdoid tumor 4369 4.00236825087534E-4
primary pancreatic ductal adenocarcinoma 1271 6.48376694108504E-4
interstitial cystitis 2299 0.0015303065946953
intraductal papillary-mucinous adenoma (IPMA) 2956 0.00202149014370584
pancreatic carcinoma 567 0.0023532584469802
non diabetic and post-ischemic heart failure 200 0.00387081516589581
intraductal papillary-mucinous carcinoma (IPMC) 2988 0.00461301850940472
medulloblastoma 1524 0.00490958844590957
osteosarcoma 7933 0.00647930433499642
oligodendroglioma 2849 0.00650156155689216
pediatric high grade glioma 2712 0.00980044688066366
gastric cancer 436 0.0107380608850163
astrocytic glioma 2241 0.0192428359915585
chronic rhinosinusitis 512 0.0280033766525708
pilocytic astrocytoma 3086 0.0349838989480903
spina bifida 1064 0.0434071955151098
aldosterone-producing adenoma 664 0.0464145693820362
Disease Target Count Z-score Confidence
Crohn's disease 304 0.0 2.0
Type 1 diabetes mellitus 104 0.0 1.0
Disease Target Count Z-score Confidence
Systemic scleroderma 66 3.456 1.7
Cancer 2346 3.257 1.6



Accession P15408 B2RD58 B3KP27 B4DYV4 Q6FG46 FRA-2
Symbols FRA2


PANTHER Protein Class (1)

  Ortholog (11)

Species Source
Macaque OMA EggNOG Inparanoid
Mouse OMA EggNOG Inparanoid
Dog OMA EggNOG Inparanoid
Horse OMA EggNOG Inparanoid
Cow OMA EggNOG Inparanoid
Opossum EggNOG Inparanoid
Platypus OMA EggNOG
Chicken OMA EggNOG Inparanoid
Anole lizard OMA EggNOG Inparanoid
Xenopus OMA EggNOG Inparanoid
Zebrafish OMA EggNOG Inparanoid

Gene RIF (18)

26581505 The binding and expression of c-Fos/Fra-2 increased as a function of severity of tongue lesions, yet selective participation of c-Jun appears to promote poor differentiation and aggressive tumorigenesis.
25375657 FOSL2 facilitates TGF-beta1-induced migration by interaction with Smad3 in non-small cell lung cancer.FOSL2 positively regulates TGF-beta1 signalling .
24587342 FRA2 is a STAT5 target gene regulated by IL-2 in human CD4 T cells.
23482931 SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma.
23339184 we show that the suppression was mediated, at least in part, by a suspension culture-driven decrease in the levels of two members of the AP1 transcription factor complex, c-Jun and Fra2
22523431 This study suggests that Fra-2 transgenic mice as an animal model of systemic sclerosis-associated pulmonary arterial hypertension display main characteristic features of the human disease.
22493372 results demonstrate the presence of a common oncogenic cascade initiated by FRA2/JUND in CCR4-expressing mature T-cell malignancies such as ATLL and CTCLs
22326952 FOSL2 is a critical regulator of leptin expression in adipocytes
20837772 These findings reveal a novel function of Fra-2/AP-1 as a positive regulator of bone and matrix formation in mice and humans.
20675274 Results suggest that Fra-2 protein may be more effective than ATF-2 protein in cyst formation originated from epithelial cells of dental follicles.

AA Sequence


Text Mined References (51)

PMID Year Title
27107012 2016 Pooled-matrix protein interaction screens using Barcode Fusion Genetics.
26581505 2015 Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer.
26496610 2015 A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
25772364 2015 SUMO-2 Orchestrates Chromatin Modifiers in Response to DNA Damage.
25755297 2015 System-wide Analysis of SUMOylation Dynamics in Response to Replication Stress Reveals Novel Small Ubiquitin-like Modified Target Proteins and Acceptor Lysines Relevant for Genome Stability.
25609649 2015 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
25416956 2014 A proteome-scale map of the human interactome network.
25375657 2014 FOSL2 positively regulates TGF-?1 signalling in non-small cell lung cancer.
25218447 2014 Uncovering global SUMOylation signaling networks in a site-specific manner.
25114211 2014 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.