Tchem ATP6V1B1 V-type proton ATPase subunit B, kidney isoform

Protein Summary

Description

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain B subunit isoforms and is found in the kidney. Mutations in this gene cause distal renal tubular acidosis associated with sensorineural deafness. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P15313
• Q53FY0
• Q6P4H6
• V-ATPase subunit B 1

Gene Name

• ATP6V1B1

Ensembl ID

• ENST00000234396
• ENSP00000234396
• ENSG00000116039

Symbol

• ATP6B1
• VATB
• VPP3
• VATB
• VMA2
• VPP3
• RTA1B
• ATP6B1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.98
protein domain	0.92
hub protein	0.9
gene perturbation	0.89
biological process	0.82

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Ligand-gated Ion Channel / V-type Proton Atpase Subunit B, Kidney Isoform

Protein / Transporter / Ion Channel / Anion Channel / V-type Proton Atpase Subunit B, Kidney Isoform

Protein / Transporter / Cation Transporter / Atp Synthase / V-type Proton Atpase Subunit B, Kidney Isoform

Protein / Receptor / Ligand-gated Ion Channel / V-type Proton Atpase Subunit B, Kidney Isoform

Protein / Nucleic Acid Binding / Dna Binding Protein / V-type Proton Atpase Subunit B, Kidney Isoform

Protein / Hydrolase / V-type Proton Atpase Subunit B, Kidney Isoform

DTO Classes

Protein / Transporter / F-type And V-type Atpases / V-type Atpase / V-type Proton Atpase Subunit B, Kidney Isoform

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.58   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 337   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.58   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0