Property Summary

NCBI Gene PubMed Count 92
PubMed Score 633.68
PubTator Score 218.86

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
lung carcinoma 2844 2.13238275644386E-31
periodontitis 269 8.47492395364698E-30
ovarian cancer 8492 1.88506187382232E-9
ulcerative colitis 2087 1.27393612251013E-6
malignant mesothelioma 3163 1.45304131292531E-6
cystic fibrosis 1670 1.7555312415513E-6
posterior fossa group A ependymoma 1511 2.1164170770546E-5
pilocytic astrocytoma 3086 4.24332480243289E-5
primary Sjogren syndrome 789 1.0051057942398E-4
pancreatic cancer 2300 1.29008044093284E-4
lung cancer 4473 1.58405801423159E-4
cutaneous lupus erythematosus 1056 4.222575984723E-4
Waldenstrons macroglobulinemia 765 6.25494744043371E-4
primary pancreatic ductal adenocarcinoma 1271 8.68628712665054E-4
osteosarcoma 7933 0.00100464562483524
pediatric high grade glioma 2712 0.00123589126240307
interstitial cystitis 2299 0.00165407478253992
glioblastoma 5572 0.00318396307325693
invasive ductal carcinoma 2950 0.00562102465805951
psoriasis 6685 0.00916529381576677
chronic kidney disease 90 0.0172877896349464
ductal carcinoma in situ 1745 0.0297995702795979
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.038810299947143
Disease Target Count Z-score Confidence
Cancer 2346 3.759 1.9


  Differential Expression (23)


Accession P15153 Q9UDJ4
Symbols Gx



1DS6   2W2T   2W2V   2W2X  

  Ortholog (11)

Species Source
Mouse OMA Inparanoid
Rat OMA Inparanoid
Dog OMA Inparanoid
Horse OMA Inparanoid
Cow OMA Inparanoid
Opossum OMA Inparanoid
Platypus OMA Inparanoid
Chicken OMA Inparanoid
Anole lizard OMA Inparanoid
Zebrafish OMA Inparanoid
C. elegans OMA Inparanoid

Gene RIF (49)

26867574 RAC1/RAC2 and SFK are proximal and essential for phosphatidylinositol 3-kinase (PI3K) activation in NK cell-mediated direct cytotoxicity against Cryptococcus neoformans.
26016997 RAC2 specifically interacted with a set of mitochondrial proteins.
25823784 our present analysis reinforces the involvement in ACT of the regulatory NADPH oxidase subunit RAC2 gene variant rs13058338 and, to a lesser extent of the CYBA gene variant rs4673.
25512081 homozygous loss-of-function RAC2 mutation in 2 patients with early-onset and progressive hypogammaglobulinemia(novel homozygous nonsense mutation in codon 56 (W56X)of RAC2 gene)
23875749 These studies imply functional importance of iNOS and its interaction with Rac2 in pathogen killing by the neutrophils.
23870057 p47(phox) and Rac2 accumulate only transiently at the phagosome at the onset of NADPH activity and detach from the phagosome before the end of reactive oxygen species production.
23850828 Mutations in hematopoiesis-specific Rho GTPases Rac2 and RhoH lead to a wide range of human blood disorders. (Review)
23591873 findings indicate that a chemokine-controlled pathway, consisting of Galphai2, ELMO1/Dock180, Rac1 and Rac2, regulates the actin cytoskeleton during breast cancer metastasis
23382236 study identified several missense mutations for RAC1 and RAC2, with some of the mutant proteins, including RAC1(P29S), RAC1(C157Y), RAC2(P29L), and RAC2(P29Q), being found to be activated and transforming; activating mutations of RAC GTPases were thus found in a wide variety of cancers at a low frequency
22411871 Rac2 GTPase alters mitochondrial membrane potential and electron flow through the mitochondrial respiratory chain complex III, generating high levels of reactive oxygen species in chronic-phase CML stem cells and primitive leukemia progenitor cells.

AA Sequence


Text Mined References (97)

PMID Year Title
26867574 2016 Ras-related C3 Botulinum Toxin Substrate (Rac) and Src Family Kinases (SFK) Are Proximal and Essential for Phosphatidylinositol 3-Kinase (PI3K) Activation in Natural Killer (NK) Cell-mediated Direct Cytotoxicity against Cryptococcus neoformans.
26016997 2015 Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25823784 2015 Association of NADPH oxidase polymorphisms with anthracycline-induced cardiotoxicity in the RICOVER-60 trial of patients with aggressive CD20(+) B-cell lymphoma.
25512081 2015 RAC2 loss-of-function mutation in 2 siblings with characteristics of common variable immunodeficiency.
24709693 2014 Genome-wide data reveal novel genes for methotrexate response in a large cohort of juvenile idiopathic arthritis cases.
24270810 2013 High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy.
24141704 2013 A bacterial toxin catalyzing tyrosine glycosylation of Rho and deamidation of Gq and Gi proteins.
23875749 2014 Interaction of inducible nitric oxide synthase with rac2 regulates reactive oxygen and nitrogen species generation in the human neutrophil phagosomes: implication in microbial killing.
23870057 2013 The recruitment of p47(phox) and Rac2G12V at the phagosome is transient and phosphatidylserine dependent.