Tbio UQCRB Cytochrome b-c1 complex subunit 7

Protein Summary

Description

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping. This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• P14927
• E5RJU0
• Q6FGD1

Gene Name

• UQCRB

Ensembl ID

• ENST00000287022
• ENSP00000287022
• ENSG00000156467
• ENST00000518406
• ENSP00000430494

Symbol

• UQBP
• QPC
• QCR7
• QP-C
• UQBC
• UQBP
• UQPC
• UQCR6
• MC3DN3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	0.97
co-expressed gene	0.91
transcription factor perturbation	0.91
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Reductase / Cytochrome B-c1 Complex Subunit 7

DTO Classes

Protein / Enzyme / Oxidoreductase / Reductase / Cytochrome B-c1 Complex Subunit 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.72   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0