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Tchem
SLC2A4
Solute carrier family 2, facilitated glucose transporter member 4

Protein Summary
Description
Insulin-regulated facilitative glucose transporter. This gene is a member of the solute carrier family 2 (facilitated glucose transporter) family and encodes a protein that functions as an insulin-regulated facilitative glucose transporter. In the absence of insulin, this integral membrane protein is sequestered within the cells of muscle and adipose tissue. Within minutes of insulin stimulation, the protein moves to the cell surface and begins to transport glucose across the cell membrane. Mutations in this gene have been associated with noninsulin-dependent diabetes mellitus (NIDDM). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317370
  • ENSP00000320935
  • ENSG00000181856
  • ENST00000572485
  • ENSP00000461086

Symbol
  • GLUT4
  • GLUT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
chemical
0.89
histone modification site profile
0.88
protein domain
0.73
co-expressed gene
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3124.07   (req: < 5)
Gene RIFs: 168   (req: <= 3)
Antibodies: 716   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3124.07   (req: >= 5)
Gene RIFs: 168   (req: > 3)
Antibodies: 716   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0