Tchem INSRR Insulin receptor-related protein

Protein Summary

Description

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB.

Uniprot Accession IDs

• P14616
• O60724
• Q5VZS3
• IRR

Gene Name

• INSRR

Ensembl ID

• ENST00000368195
• ENSP00000357178
• ENSG00000027644

Symbol

• IRR
• IRR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
gene perturbation	0.57
tissue	0.53
cell line	0.51

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Insr Family / Insulin Receptor-related Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.9   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 359   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.9   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1