Property Summary

NCBI Gene PubMed Count 174
PubMed Score 723.71
PubTator Score 1041.29

Knowledge Summary


No data available


  Disease Sources (4)

Disease Target Count P-value
ovarian cancer 8492 1.08500792837664E-12
Duchenne muscular dystrophy 602 2.32190950762772E-7
pilocytic astrocytoma 3086 7.55345930367328E-7
acute quadriplegic myopathy 1157 5.14163229069354E-6
glioblastoma multiforme 347 1.61639606270889E-5
lung cancer 4473 9.67447882193543E-5
adult high grade glioma 2148 2.28142143920625E-4
non diabetic and post-ischemic heart failure 200 3.31625541535599E-4
limb girdle muscular dystrophy 2B 74 4.68217316406321E-4
pancreatic ductal adenocarcinoma liver metastasis 1795 0.00132020574134414
psoriasis 6685 0.00146637367127359
cystic fibrosis 1670 0.00164612599196271
head and neck cancer and chronic obstructive pulmonary disease 237 0.00185527146897137
non-small cell lung cancer 2798 0.00439421109683704
active Crohn's disease 918 0.00707089534008242
ulcerative colitis 2087 0.00719382809557797
pituitary cancer 1972 0.0102461168242403
interstitial cystitis 2299 0.0163708906420636
subependymal giant cell astrocytoma 2287 0.0338025663684496
type II diabetes mellitus and post-ischemic heart failure 89 0.0363801071036988
osteosarcoma 7933 0.037110881583625
X-linked recessive Emery-Dreifuss muscular dystrophy 18 0.0417382103693799
Disease Target Count
Carcinoma of colon 32



Accession P14555 A8K5I7 Q6DN24 Q6IBD9 Q9UCD2
Symbols MOM1


PANTHER Protein Class (3)


1AYP   1BBC   1DB4   1DB5   1DCY   1J1A   1KQU   1KVO   1N28   1N29   1POD   1POE   2GNY   3U8B   3U8D   3U8H   3U8I   5G3N  

  Ortholog (5)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG Inparanoid
Rat OMA EggNOG Inparanoid
Cow OMA Inparanoid

 MGI Term (1)

Gene RIF (139)

26644377 IL-22 induced at an early stage of L. monocytogenes infection enhances innate immunity against L. monocytogenes in the liver by stimulating hepatocytes to produce PLA2G2A
26506412 These results suggest that the genetic ablation of iPLA2b increased iron uptake in the brain through the activation of IRP2 and upregulation of DMT1, which may be associated with mitochondrial dysfunction.
26488172 Overexpression of sPLA2-IIA does not alter MCP-1 level at baseline, but could enhance the atherogenic effect of oxidized LDL in HASMCs, at least partly due to activation of Akt.
26106157 Results indicate that secreted phospholipase A2 IIA (sPLA2-IIA) as an enzyme working in concert with platelet microparticles (MPs) 12-lipoxygenase (12-LO) to promote internalization.
25794429 The minor allele of rs11573156, is a dominant haplotype and is associated with the higher sPLA2-IIa levels.
25713085 Activity of iPLbeta correlates inversely with the hydrophobicity of the phospholipid substrate.
25429648 sPLA2 are secreted from ciliated cells and appear to induce mucin and cysLT secretion from goblet cells, strongly suggesting that airway goblet cells are proinflammatory effector cells.
25422234 Co-expression of PLA2G2A and COX-2 significantly correlated with the depth of invasion (p=0.004)and with TNM stage (p=0.04) of esophageal squamous cell carcinoma
25398877 Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrin alphaVbeta3, integrin alphavbeta1, and integrin alpha4beta1.
25366587 PLA2G2A was detected in all samples of endometriomas, but not in normal endometrium, and immunohistochemistry showed PLA2G2A-specific staining in epithelial cells of endometrioma paraffin sections.

AA Sequence

TPRC                                                                      141 - 144

Text Mined References (176)

PMID Year Title
26644377 2015 Interleukin-22-Induced Antimicrobial Phospholipase A2 Group IIA Mediates Protective Innate Immunity of Nonhematopoietic Cells against Listeria monocytogenes.
26506412 2015 Deficiency of Calcium-Independent Phospholipase A2 Beta Induces Brain Iron Accumulation through Upregulation of Divalent Metal Transporter 1.
26488172 2015 sPLA2-IIA Augments Oxidized LDL-Induced MCP-1 Expression in Vitro Through Activation of Akt.
26106157 2015 Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA.
25794429 2015 The association of PLA2G2A single nucleotide polymorphisms with type IIa secretory phospholipase A2 level but not its activity in patients with stable coronary heart disease.
25713085 2015 Substrate efflux propensity is the key determinant of Ca2+-independent phospholipase A-? (iPLA?)-mediated glycerophospholipid hydrolysis.
25429648 2015 Secretory phospholipases A2 are secreted from ciliated cells and increase mucin and eicosanoid secretion from goblet cells.
25422234 2014 Overexpression of phospholipase A2 Group IIA in esophageal squamous cell carcinoma and association with cyclooxygenase-2 expression.
25398877 2015 Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a newly identified binding site (site 2) in integrins ?v?3, ?4?1, and ?5?1.
25366587 2015 Phospholipase A2 group IIA is elevated in endometriomas but not in peritoneal fluid and serum of ovarian endometriosis patients.