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Tclin
DRD2
D(2) dopamine receptor

Protein Summary
Description
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346454
  • ENSP00000278597
  • ENSG00000149295
  • ENST00000362072
  • ENSP00000354859
  • ENST00000538967
  • ENSP00000438215
  • ENST00000542968
  • ENSP00000442172

Symbol
  • D2R
  • D2DR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
drug
1
ligand (chemical)
1
molecular function
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3685.77   (req: < 5)
Gene RIFs: 971   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3685.77   (req: >= 5)
Gene RIFs: 971   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 103
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3210
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 81