Tbio PRKCSH Glucosidase 2 subunit beta

Protein Summary

Description

Regulatory subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). This gene encodes the beta-subunit of glucosidase II, an N-linked glycan-processing enzyme in the endoplasmic reticulum. The encoded protein is an acidic phosphoprotein known to be a substrate for protein kinase C. Mutations in this gene have been associated with the autosomal dominant polycystic liver disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Uniprot Accession IDs

• P14314
• A8K318
• Q96BU9
• Q96D06
• Q9P0W9

Gene Name

• PRKCSH

Ensembl ID

• ENST00000587327
• ENSP00000466012
• ENSG00000130175
• ENST00000589838
• ENSP00000465461
• ENST00000591462
• ENSP00000465489

Symbol

• G19P1
• GIIB
• PCLD
• PLD1
• G19P1
• PCLD1
• PKCSH
• AGE-R2
• VASAP-60

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.99
co-expressed gene	0.96
transcription factor binding site profile	0.93
histone modification site profile	0.89
kinase perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Transferase / Glucosidase 2 Subunit Beta

Protein / Enzyme Modulator / Glucosidase 2 Subunit Beta

DTO Classes

Protein / Enzyme / Transferase / Glucosidase 2 Subunit Beta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.17   (req: < 5)

Gene RIFs: 23   (req: <= 3)

Antibodies: 286   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 161.17   (req: >= 5)

Gene RIFs: 23   (req: > 3)

Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0