Property Summary

NCBI Gene PubMed Count 96
PubMed Score 449.42
PubTator Score 709.31

Knowledge Summary

Patent

No data available

TINX Plot

  Disease Sources (3)

Disease Target Count
Chondrosarcoma, Mesenchymal 5
Disease Target Count P-value
glioblastoma multiforme 347 2.16741023013763E-27
lung carcinoma 2844 3.65976164946695E-22
Duchenne muscular dystrophy 602 3.44359460854588E-11
ovarian cancer 8492 1.00246498222534E-7
pediatric high grade glioma 2712 1.86466487288949E-7
limb girdle muscular dystrophy 2A 156 2.05199254074444E-7
Breast cancer 3099 2.5168494001834E-6
lung cancer 4473 3.2343173622234E-5
pituitary cancer 1972 6.54156089084774E-5
pilocytic astrocytoma 3086 1.0275711581516E-4
intraductal papillary-mucinous adenoma (IPMA) 2956 4.34914950923295E-4
Down syndrome 548 9.97871124326566E-4
astrocytoma 1493 0.00302290701178351
atypical teratoid / rhabdoid tumor 4369 0.00417102107994195
ependymoma 2514 0.0108140944485801
intraductal papillary-mucinous neoplasm (IPMN) 3289 0.0154243303888759
Rheumatoid Arthritis 1171 0.0162951318613192
pancreatic ductal adenocarcinoma liver metastasis 1795 0.0181627557617938
oligodendroglioma 2849 0.0255133544849652
psoriasis 6685 0.039388853311619
osteosarcoma 7933 0.0415093555992642

Expression

  Differential Expression (21)

Synonym

Accession P14209 A6NIW1 O00518 Q6ICV7
Symbols MIC2
HBA71
MIC2X
MIC2Y
MSK5X

Gene

PANTHER Protein Class (1)

  Ortholog (10)

Species Source
Chimp OMA EggNOG
Macaque OMA EggNOG
Rat OMA Inparanoid
Dog OMA EggNOG
Cow OMA EggNOG
Opossum OMA EggNOG Inparanoid
Platypus OMA EggNOG Inparanoid
Chicken OMA Inparanoid
Xenopus OMA Inparanoid
Zebrafish OMA Inparanoid

 GO Process (1)

Gene RIF (63)

PMID Text
26522646 Data show that CD99 antigen expression increased during in vitro differentiation of germinal center B cells and was highest in plasma cells (PCs).
26172215 CD99 can suppress CD98-mediated assembly of pro-tumorigenic signaling complexes through its ability to dephosphorylate focal adhesion kinase.
26000982 These results suggest that SEPTIN2-mediated cytoskeletal rearrangement and STATHMIN-mediated differentiation may contribute to changes in cell morphology and differentiation of H/RS cells with CD99 upregulation in Hodgkin lymphoma.
26000312 The results highlight an important role of CD99 in the differentiation and activity of human osteoblasts in physiological and pathological conditions.
25957287 Our results suggest that the CD34/CD25/CD123/CD99(+) LAIP is strictly associated with FLT3-ITD-positive cells.
25501132 The dAbd C7 induced rapid and massive EWS cell death through Mdm2 degradation and p53 reactivation. Mdm2 overexpression as well as silencing of p53 in p53wt EWS cells decreased CD99-induced EWS cell death
24798881 Report purification of human antibody scFv anti-CD99 for blocking monocyte transendothelial migration.
24797829 CD99 expression in astrocytomas of different malignant grades might contribute to the infiltrative ability and support the importance of CD99 as a potential target to reduce infiltrative astrocytoma capacity in migration and invasion.
24702676 CD99 expression in nasal lobular capillary haemangioma.
24677094 CD99 induces ERK activation, increasing its membrane-bound/cytoplasmic form rather than affecting its nuclear localization.
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AA Sequence

MARGAALALLLFGLLGVLVAAPDGGFDLSDALPDNENKKPTAIPKKPSAGDDFDLGDAVVDGENDDPRPP      1 - 70
NPPKPMPNPNPNHPSSSGSFSDADLADGVSGGEGKGGSDGGGSHRKEGEEADAPGVIPGIVGAVVVAVAG     71 - 140
AISSFIAYQKKKLCFKENAEQGEVDMESHRNANAEPAVQRTLLEK                             141 - 185
//

Text Mined References (101)

PMID Year Title
26522646 2015 CD99 regulates CXCL12-induced chemotaxis of human plasma cells.
26172215 2015 CD99 inhibits CD98-mediated ?1 integrin signaling through SHP2-mediated FAK dephosphorylation.
26000982 2015 SEPTIN2 and STATHMIN Regulate CD99-Mediated Cellular Differentiation in Hodgkin's Lymphoma.
26000312 2015 Human myeloma cell lines induce osteoblast downregulation of CD99 which is involved in osteoblast formation and activity.
25957287 2015 A Leukemia-Associated CD34/CD123/CD25/CD99+ Immunophenotype Identifies FLT3-Mutated Clones in Acute Myeloid Leukemia.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25501132 2015 CD99 triggering in Ewing sarcoma delivers a lethal signal through p53 pathway reactivation and cooperates with doxorubicin.
24798881 2014 Blocking monocyte transmigration in in vitro system by a human antibody scFv anti-CD99. Efficient large scale purification from periplasmic inclusion bodies in E. coli expression system.
24797829 2014 CD99 is upregulated in placenta and astrocytomas with a differential subcellular distribution according to the malignancy stage.
24702676 2014 CD99 expression in nasal lobular capillary haemangioma.
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