Tchem MIF Macrophage migration inhibitory factor

Protein Summary

Description

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P14174
• A5Z1R8
• B2R4S3
• Q2V4Y5
• Q6FHV0
• MIF

Gene Name

• MIF

Ensembl ID

• ENST00000215754
• ENSP00000215754
• ENSG00000240972
• ENST00000613839
• ENSP00000482779
• ENSG00000276701

Symbol

• GLIF
• MMIF
• GIF
• GLIF
• MMIF

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
kinase perturbation	0.96
hub protein	0.92
disease	0.9
gene perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1688.45   (req: < 5)

Gene RIFs: 712   (req: <= 3)

Antibodies: 675   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1688.45   (req: >= 5)

Gene RIFs: 712   (req: > 3)

Antibodies: 675   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 74

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0