Tclin ADRB3 Beta-3 adrenergic receptor

Protein Summary

Description

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq, Feb 2009]

Uniprot Accession IDs

• P13945
• Q4JFT4

Gene Name

• ADRB3

Ensembl ID

• ENST00000345060
• ENSP00000343782
• ENSG00000188778

Symbol

• ADRB3R
• B3AR
• BETA3AR

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.93
drug	0.85
molecular function	0.81
ligand (chemical)	0.8
chemical	0.77

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Beta-3 Adrenergic Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Adrenoceptor / Beta Adrenoceptor / Beta-3 Adrenergic Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 918.11   (req: < 5)

Gene RIFs: 227   (req: <= 3)

Antibodies: 371   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 918.11   (req: >= 5)

Gene RIFs: 227   (req: > 3)

Antibodies: 371   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1076

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13